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Annals of Intensive Care
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Table 1 Characteristics of patients admitted with ARF according to initial ventilator strategy

From: Acute respiratory failure in patients with hematological malignancies: outcomes according to initial ventilation strategy. A groupe de recherche respiratoire en réanimation onco-hématologique (Grrr-OH) study

Variables Patients receiving oxygen only (n = 238) Patient receiving NIV (n = 142) p Std diff
Baseline characteristics
 Age (year) m, [IQR] 60 [49–67] 60 [50–70] 0.15 0.14
 Gender male 102 (42) 57 (40) 0.67 0.06
 Underlying disease    0.27  
  Myeloid disease 84 (35) 57 (40)   0.10
  Lymphoid disease 109 (46) 53 (37)   0.17
  Other 45 (19) 32 (22)   0.09
 Delay from diagnosis to ICU admission
  Newly diagnosed 85 (36) 30 (21)   
  Remission 58 (24) 41 (29) 0.05  
  No remission 91 (38) 41 (29)   
 Allogenic stem cell transplantation 41 (17) 33 (23) 0.18 0.15
 Performance status >2 (severely disabled or bedridden) 36 (15) 36 (25) 0.015 0.26
 Charlson comorbidity score 4 [2–5] 4 [3–5] 0.73 0.03
 Delay from hospital to ICU admission (days) 4 [0–19] 7 [1–21] 0.29 0.13
 Admission from emergency department 61 (26) 29 (20) 0.26 0.12
 Neutropenia at admission 65 (27) 47 (33) 0.25 0.13
 ARF etiology    0.20  
  Infection 104 (43) 57 (40)   0.07
  Cardiogenic edema 21 (9) 22 (15)   0.20
  Malignant Infiltration 39 (16) 26 (18)   0.05
  Othera 74 (31) 37 (26)   0.11
 Maximum respiratory rate at day 1 31 [25–36] 35 [30–41] <0.001 0.57
 Shock at day 1 40 (17) 23 (16) 1 0.02
 Acute kidney injury at day 1 40 (17) 23 (16) 1 0.02
 SOFA score at day 1 > 7 34 (15) 47 (36) <0.001 0.51
 Do not intubate order day 1 or day 2 7 (2.9) 8 (5.6) 0.23 0.09
VNI parameters
 Number of trial/day (day1)   2.5 (2–4)   
 Number of trial/day (day2)   2 (2–5)   
 Length of NIV (h) (day 1)   4 (2–8)   
 Length of NIV (h) (day 2)   5 (3–9)   
 Respiratory rate under NIV at day 1   26 (20–32)   
 Pressure support day 1 (cm H2O)   10 (8–12.7)   
 Pressure support day 2 (cm H2O)   10 (8–14)   
 PEEP at day 1 (cm H2O)   5 (5–7)   
 PEEP at day 2 (cm H2O)   5 (5–6)   
Outcome
 Intubation throughout the ICU stay 48 (20) 46 (32) 0.01  
 Time from admission to intubation 3 [2–5] 3 [2–5] 0.85  
 ICU length of stay 5 [2–9] 7 [4–20] <0.001  
 ICU-acquired infection 27 (11) 21 (15) 0.34  
 Hospital mortality 61 (26) 62 (44) <0.001  
 Hospital mortality of intubated patients 27/48 (56) 35/46 (76) 0.05  
  1. All data are presented as medians [25th–75th percentiles] for quantitative variables and frequencies (percentage) for qualitative variables. Comparisons between the two groups were performed with Chi-square test for qualitative value and Wilcoxon test for quantitative value
  2. SOFA score Sequential Organ Failure Assessment score
  3. aOther included undetermined diagnosis (n = 94, 84.6 % of other diagnosis)
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