Table 1 Characteristics of patients admitted with ARF according to initial ventilator strategy
Variables | Patients receiving oxygen only (n = 238) | Patient receiving NIV (n = 142) | p | Std diff |
|---|---|---|---|---|
Baseline characteristics | ||||
Age (year) m, [IQR] | 60 [49–67] | 60 [50–70] | 0.15 | 0.14 |
Gender male | 102 (42) | 57 (40) | 0.67 | 0.06 |
Underlying disease | 0.27 | |||
Myeloid disease | 84 (35) | 57 (40) | 0.10 | |
Lymphoid disease | 109 (46) | 53 (37) | 0.17 | |
Other | 45 (19) | 32 (22) | 0.09 | |
Delay from diagnosis to ICU admission | ||||
Newly diagnosed | 85 (36) | 30 (21) | ||
Remission | 58 (24) | 41 (29) | 0.05 | |
No remission | 91 (38) | 41 (29) | ||
Allogenic stem cell transplantation | 41 (17) | 33 (23) | 0.18 | 0.15 |
Performance status >2 (severely disabled or bedridden) | 36 (15) | 36 (25) | 0.015 | 0.26 |
Charlson comorbidity score | 4 [2–5] | 4 [3–5] | 0.73 | 0.03 |
Delay from hospital to ICU admission (days) | 4 [0–19] | 7 [1–21] | 0.29 | 0.13 |
Admission from emergency department | 61 (26) | 29 (20) | 0.26 | 0.12 |
Neutropenia at admission | 65 (27) | 47 (33) | 0.25 | 0.13 |
ARF etiology | 0.20 | |||
Infection | 104 (43) | 57 (40) | 0.07 | |
Cardiogenic edema | 21 (9) | 22 (15) | 0.20 | |
Malignant Infiltration | 39 (16) | 26 (18) | 0.05 | |
Othera | 74 (31) | 37 (26) | 0.11 | |
Maximum respiratory rate at day 1 | 31 [25–36] | 35 [30–41] | <0.001 | 0.57 |
Shock at day 1 | 40 (17) | 23 (16) | 1 | 0.02 |
Acute kidney injury at day 1 | 40 (17) | 23 (16) | 1 | 0.02 |
SOFA score at day 1 > 7 | 34 (15) | 47 (36) | <0.001 | 0.51 |
Do not intubate order day 1 or day 2 | 7 (2.9) | 8 (5.6) | 0.23 | 0.09 |
VNI parameters | ||||
Number of trial/day (day1) | 2.5 (2–4) | |||
Number of trial/day (day2) | 2 (2–5) | |||
Length of NIV (h) (day 1) | 4 (2–8) | |||
Length of NIV (h) (day 2) | 5 (3–9) | |||
Respiratory rate under NIV at day 1 | 26 (20–32) | |||
Pressure support day 1 (cm H2O) | 10 (8–12.7) | |||
Pressure support day 2 (cm H2O) | 10 (8–14) | |||
PEEP at day 1 (cm H2O) | 5 (5–7) | |||
PEEP at day 2 (cm H2O) | 5 (5–6) | |||
Outcome | ||||
Intubation throughout the ICU stay | 48 (20) | 46 (32) | 0.01 | |
Time from admission to intubation | 3 [2–5] | 3 [2–5] | 0.85 | |
ICU length of stay | 5 [2–9] | 7 [4–20] | <0.001 | |
ICU-acquired infection | 27 (11) | 21 (15) | 0.34 | |
Hospital mortality | 61 (26) | 62 (44) | <0.001 | |
Hospital mortality of intubated patients | 27/48 (56) | 35/46 (76) | 0.05 | |