Baseline characteristics
|
Age (year) m, [IQR]
|
60 [49–67]
|
60 [50–70]
|
0.15
|
0.14
|
Gender male
|
102 (42)
|
57 (40)
|
0.67
|
0.06
|
Underlying disease
| | |
0.27
| |
Myeloid disease
|
84 (35)
|
57 (40)
| |
0.10
|
Lymphoid disease
|
109 (46)
|
53 (37)
| |
0.17
|
Other
|
45 (19)
|
32 (22)
| |
0.09
|
Delay from diagnosis to ICU admission
|
Newly diagnosed
|
85 (36)
|
30 (21)
| | |
Remission
|
58 (24)
|
41 (29)
|
0.05
| |
No remission
|
91 (38)
|
41 (29)
| | |
Allogenic stem cell transplantation
|
41 (17)
|
33 (23)
|
0.18
|
0.15
|
Performance status >2 (severely disabled or bedridden)
|
36 (15)
|
36 (25)
|
0.015
|
0.26
|
Charlson comorbidity score
|
4 [2–5]
|
4 [3–5]
|
0.73
|
0.03
|
Delay from hospital to ICU admission (days)
|
4 [0–19]
|
7 [1–21]
|
0.29
|
0.13
|
Admission from emergency department
|
61 (26)
|
29 (20)
|
0.26
|
0.12
|
Neutropenia at admission
|
65 (27)
|
47 (33)
|
0.25
|
0.13
|
ARF etiology
| | |
0.20
| |
Infection
|
104 (43)
|
57 (40)
| |
0.07
|
Cardiogenic edema
|
21 (9)
|
22 (15)
| |
0.20
|
Malignant Infiltration
|
39 (16)
|
26 (18)
| |
0.05
|
Othera
|
74 (31)
|
37 (26)
| |
0.11
|
Maximum respiratory rate at day 1
|
31 [25–36]
|
35 [30–41]
|
<0.001
|
0.57
|
Shock at day 1
|
40 (17)
|
23 (16)
|
1
|
0.02
|
Acute kidney injury at day 1
|
40 (17)
|
23 (16)
|
1
|
0.02
|
SOFA score at day 1 > 7
|
34 (15)
|
47 (36)
|
<0.001
|
0.51
|
Do not intubate order day 1 or day 2
|
7 (2.9)
|
8 (5.6)
|
0.23
|
0.09
|
VNI parameters
|
Number of trial/day (day1)
| |
2.5 (2–4)
| | |
Number of trial/day (day2)
| |
2 (2–5)
| | |
Length of NIV (h) (day 1)
| |
4 (2–8)
| | |
Length of NIV (h) (day 2)
| |
5 (3–9)
| | |
Respiratory rate under NIV at day 1
| |
26 (20–32)
| | |
Pressure support day 1 (cm H2O)
| |
10 (8–12.7)
| | |
Pressure support day 2 (cm H2O)
| |
10 (8–14)
| | |
PEEP at day 1 (cm H2O)
| |
5 (5–7)
| | |
PEEP at day 2 (cm H2O)
| |
5 (5–6)
| | |
Outcome
|
Intubation throughout the ICU stay
|
48 (20)
|
46 (32)
|
0.01
| |
Time from admission to intubation
|
3 [2–5]
|
3 [2–5]
|
0.85
| |
ICU length of stay
|
5 [2–9]
|
7 [4–20]
|
<0.001
| |
ICU-acquired infection
|
27 (11)
|
21 (15)
|
0.34
| |
Hospital mortality
|
61 (26)
|
62 (44)
|
<0.001
| |
Hospital mortality of intubated patients
|
27/48 (56)
|
35/46 (76)
|
0.05
| |