Baseline characteristics
|
Age (year) m, [IQR]
|
60 [47–67]
|
61 [49.5–68]
|
0.05
|
Gender male (%)
|
23 (41.8)
|
20 (36.6)
|
0.11
|
Underlying malignancy
|
Myeloid disease
|
27 (49)
|
22 (40)
|
0.18
|
Lymphoid disease
|
18 (32.7)
|
19 (34.5)
|
0.04
|
Other
|
10 (18.1)
|
14 (25.4)
|
0.17
|
Remission
|
16 (29)
|
18 (32.7)
|
0.08
|
Allogeneic stem cell transplantation
|
10 (18.8)
|
10 (18.8)
|
0
|
Performance status >2 (severely disabled or bedridden)
|
12 (21.8)
|
11 (20)
|
0.04
|
Charlson comorbidity score
|
4 [3–6]
|
4 [3–5]
|
0.01
|
Time (days) from hospital to ICU admission
|
4 [0–15]
|
6 [0–13.5]
|
0.02
|
Admission from emergency department
|
39 (71)
|
40 (72.7)
|
0.04
|
Neutropenia at ICU admission
|
39 (71)
|
37 (67.3)
|
0.08
|
ARF etiology
|
Infection
|
20 (36.4)
|
20 (36.4)
|
0
|
Cardiogenic edema
|
10 (18.2)
|
8 (14.5)
|
0.09
|
Malignant Infiltration
|
13 (23.6)
|
12 (21.8)
|
0.04
|
Othera
|
12 (21.8)
|
15 (27.3)
|
0.13
|
Maximum respiratory rate at day 1/min
|
33 [26.5–38.5]
|
32 [29–41]
|
0.14
|
Shock at day 1
|
9 (16.4)
|
9 (16.4)
|
0
|
Acute kidney injury at day 1
|
9 (16.4)
|
9 (16.4)
|
0
|
SOFA score at day 1 > 7
|
15 (27.3)
|
15 (27.3)
|
0
|
Do not intubate order day 1 or day 2
|
0 (0)
|
2 (3.6)
|
0.27
|
VNI parameters
|
Number of trial/day (day 1)
| |
3 (2–5)
| |
Number of trial/day (day 2)
| |
3.5 (1–5.2)
| |
Length of NIV (hours) (day 1)
| |
6.2 (3–9)
| |
Length of NIV (hours) (day 2)
| |
5.5 (3–9)
| |
Respiratory rate under NIV at day 1
| |
26.5 (21.5–32.5)
| |
Pressure support day 1 (cm H2O)
| |
10 (8–13)
| |
Pressure support day 2 (cm H2O)
| |
11.5 (8.5–14)
| |
PEEP at day 1 (cm H2O)
| |
6 (5–7)
| |
PEEP at day 2 (cm H2O)
| |
5 (5–7)
| |
Outcome
|
Intubation throughout the ICU stay
|
14 (25.4)
|
16 (29.1)
| |
Time from admission to intubation
|
4 [2–6]
|
3 [2–5]
| |
Length of ICU stay
|
5 [3–11]
|
6 [4–14]
| |
ICU-acquired infection
|
5 (9)
|
6 (11)
| |
Hospital mortality
|
11 (20)
|
15 (27.3)
| |
Mortality of intubated patients
|
5/14 (36)
|
7/16 (44)
| |