Variables | Oxygen therapy (n = 55) | NIV therapy (n = 55) | Std diff |
---|---|---|---|
Baseline characteristics | |||
Age (year) m, [IQR] | 60 [47–67] | 61 [49.5–68] | 0.05 |
Gender male (%) | 23 (41.8) | 20 (36.6) | 0.11 |
Underlying malignancy | |||
Myeloid disease | 27 (49) | 22 (40) | 0.18 |
Lymphoid disease | 18 (32.7) | 19 (34.5) | 0.04 |
Other | 10 (18.1) | 14 (25.4) | 0.17 |
Remission | 16 (29) | 18 (32.7) | 0.08 |
Allogeneic stem cell transplantation | 10 (18.8) | 10 (18.8) | 0 |
Performance status >2 (severely disabled or bedridden) | 12 (21.8) | 11 (20) | 0.04 |
Charlson comorbidity score | 4 [3–6] | 4 [3–5] | 0.01 |
Time (days) from hospital to ICU admission | 4 [0–15] | 6 [0–13.5] | 0.02 |
Admission from emergency department | 39 (71) | 40 (72.7) | 0.04 |
Neutropenia at ICU admission | 39 (71) | 37 (67.3) | 0.08 |
ARF etiology | |||
Infection | 20 (36.4) | 20 (36.4) | 0 |
Cardiogenic edema | 10 (18.2) | 8 (14.5) | 0.09 |
Malignant Infiltration | 13 (23.6) | 12 (21.8) | 0.04 |
Othera | 12 (21.8) | 15 (27.3) | 0.13 |
Maximum respiratory rate at day 1/min | 33 [26.5–38.5] | 32 [29–41] | 0.14 |
Shock at day 1 | 9 (16.4) | 9 (16.4) | 0 |
Acute kidney injury at day 1 | 9 (16.4) | 9 (16.4) | 0 |
SOFA score at day 1 > 7 | 15 (27.3) | 15 (27.3) | 0 |
Do not intubate order day 1 or day 2 | 0 (0) | 2 (3.6) | 0.27 |
VNI parameters | |||
Number of trial/day (day 1) | 3 (2–5) | ||
Number of trial/day (day 2) | 3.5 (1–5.2) | ||
Length of NIV (hours) (day 1) | 6.2 (3–9) | ||
Length of NIV (hours) (day 2) | 5.5 (3–9) | ||
Respiratory rate under NIV at day 1 | 26.5 (21.5–32.5) | ||
Pressure support day 1 (cm H2O) | 10 (8–13) | ||
Pressure support day 2 (cm H2O) | 11.5 (8.5–14) | ||
PEEP at day 1 (cm H2O) | 6 (5–7) | ||
PEEP at day 2 (cm H2O) | 5 (5–7) | ||
Outcome | |||
Intubation throughout the ICU stay | 14 (25.4) | 16 (29.1) | |
Time from admission to intubation | 4 [2–6] | 3 [2–5] | |
Length of ICU stay | 5 [3–11] | 6 [4–14] | |
ICU-acquired infection | 5 (9) | 6 (11) | |
Hospital mortality | 11 (20) | 15 (27.3) | |
Mortality of intubated patients | 5/14 (36) | 7/16 (44) |