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Table 4 Univariate analysis and variables associated with ICU mortality

From: Trends in use and impact on outcome of empiric antibiotic therapy and non-invasive ventilation in COPD patients with acute exacerbation

Variables

Survivors (n = 372)

Dead (n = 68)

p

Age med (IQR)

68 (60–73)

70 (62–76)

0.031

Gender (M/F)

313/58

59/10

1.000

Time course of COPD (years) med (IQR)

7 (4–15)

8.5 (3.5–15)

0.506

FEV1 (ml) med (IQR)

860 (700–1070)

900 (775–1030)

0.489

Diabetes n (%)

69 (18.6)

12 (17.4)

1.000

Cardiovascular comorbidities n (%)

107 (28.8)

27 (39.1)

0.116

Oxygen home therapy n (%)

77 (34)

16 (29.3)

0.495

SAPS II med (IQR)

27 (21–34)

32 (26–37)

0.003

pH at admission med (IQR)

7.29 (7.24–7.33)

7.25 (7.19–7.30)

0.001

NIV at admission n (%)

266 (71.7)

20 (29)

<0.001

Invasive ventilation at admission n (%)

105 (28.3)

49 (71)

<0.001

NIV failure n (%)

24 (9)

16 (80)

<0.001

Empiric antibiotic therapy at ICU admission n (%)

210 (56.6)

38 (55.1)

0.895

Bronchodilators n (%)

204 (79.7)

37 (78.7)

0.846

Systemic corticosteroids n (%)

121 (33.2)

30 (44.1)

0.097

VAP n (%)

23 (6.1)

38 (55.1)

<0.001

  1. COPD chronic obstructive pulmonary disease, FEV 1 forced expiratory volume in 1 s, SAPS Simplified Acute Physiology Score, NIV non-invasive ventilation, VAP ventilator associated pneumonia, med median, IQR inter-quartile range
  2. Variables with p value < 0.2 are presented in italic