Table 2 Medications and interventions performed on the day 0 or 1 in the unmatched and propensity-matched groups
Variable | Unadjusted | Propensity-score weighted | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Control, n = 2009 | Corticosteroid, n = 155 | Standardized difference, % | Control, n = 2164 | Corticosteroid, n = 2101 | Standardized difference, % | |||||
Blood culture taken | 911 | (45.3) | 76 | (49.0) | −7.4 | 987 | (45.6) | 1005 | (47.8) | −4.5 |
Mechanical ventilation | 1675 | (83.4) | 130 | (83.9) | −1.3 | 1805 | (83.4) | 1752 | (83.4) | 0.1 |
Intermittent hemodialysis | 255 | (12.7) | 15 | (9.7) | 9.6 | 270 | (12.5) | 229 | (10.9) | 4.9 |
Continuous renal replacement therapy | 478 | (23.8) | 31 | (20.0) | 9.2 | 509 | (23.5) | 487 | (23.2) | 0.8 |
PMX | 515 | (25.6) | 35 | (22.6) | 7.1 | 550 | (25.4) | 530 | (25.2) | 0.5 |
Catecholamines | ||||||||||
Dopamine use | 1820 | (90.6) | 128 | (82.6) | 23.7 | 1949 | (90.1) | 1895 | (90.2) | −0.4 |
Dobutamine use | 386 | (19.2) | 33 | (21.3) | −5.2 | 419 | (19.4) | 449 | (21.4) | −5.0 |
Vasopressin | 158 | (7.9) | 27 | (17.4) | −29.1 | 184 | (8.5) | 154 | (7.3) | 4.4 |
Initial antibiotic use | ||||||||||
Initial use of two or more antibiotics | 483 | (24.0) | 38 | (24.5) | −1.1 | 521 | (24.1) | 556 | (26.5) | −5.5 |
Tazobactam/piperacillin or sulbactam/cefoperazone sodium | 180 | (9.0) | 10 | (6.5) | 9.4 | 190 | (8.8) | 214 | (10.2) | −4.8 |
First-generation cephalosporin | 93 | (4.6) | 4 | (2.6) | 11.0 | 97 | (4.5) | 116 | (5.5) | −4.8 |
Second-generation cephalosporin | 758 | (37.7) | 56 | (36.1) | 3.3 | 814 | (37.6) | 810 | (38.5) | −1.9 |
Third-generation cephalosporin | 63 | (3.1) | 5 | (3.2) | −0.5 | 68 | (3.1) | 56 | (2.7) | 2.8 |
Fourth-generation cephalosporin | 46 | (2.3) | 3 | (1.9) | 2.5 | 49 | (2.3) | 39 | (1.9) | 2.9 |
Carbapenem | 1248 | (62.1) | 111 | (71.6) | −20.3 | 1359 | (62.8) | 1357 | (64.6) | −3.7 |
Antifungal drug | 34 | (1.7) | 3 | (1.9) | −1.8 | 37 | (1.7) | 41 | (2.0) | −1.8 |
Antithrombin | 646 | (32.2) | 57 | (36.8) | −9.7 | 703 | (32.5) | 740 | (35.2) | −5.8 |
rhTM | 454 | (22.6) | 38 | (24.5) | −4.5 | 492 | (22.7) | 543 | (25.8) | −7.2 |
Gabexate mesilate | 517 | (25.7) | 40 | (25.8) | −0.2 | 557 | (25.7) | 551 | (26.2) | −1.1 |
Nafamostat mesilate | 947 | (47.1) | 72 | (46.5) | 1.4 | 1019 | (47.1) | 1006 | (47.9) | −1.6 |
Ulinastatin | 545 | (27.1) | 39 | (25.2) | 4.5 | 584 | (27.0) | 493 | (23.5) | 8.1 |
Sivelestat sodium | 735 | (36.6) | 51 | (32.9) | 7.7 | 786 | (36.3) | 715 | (34.0) | 4.8 |
Immunoglobulin | 856 | (42.6) | 61 | (39.4) | 6.6 | 917 | (42.4) | 845 | (40.2) | 4.4 |
Albumin | 1614 | (80.3) | 129 | (83.2) | −7.5 | 1743 | (80.5) | 1761 | (83.8) | −8.6 |
Blood transfusion | ||||||||||
Red blood cells | 1094 | (54.5) | 88 | (56.8) | −4.7 | 1182 | (54.6) | 1196 | (56.9) | −4.6 |
Fresh frozen plasma | 1065 | (53.0) | 89 | (57.4) | −8.9 | 1154 | (53.3) | 1090 | (51.9) | 2.9 |
Platelets | 254 | (12.6) | 28 | (18.1) | −15.1 | 282 | (13.0) | 256 | (12.2) | 2.6 |
Amount of first blood transfusion | ||||||||||
No. transfusions | 833 | (41.5) | 55 | (35.5) | 12.3 | 887 | (41.0) | 796 | (37.9) | 6.4 |
<500 mL | 444 | (22.1) | 41 | (26.5) | −10.2 | 486 | (22.5) | 535 | (25.5) | −7.0 |
501–1000 mL | 556 | (27.7) | 45 | (29.0) | −3.0 | 601 | (27.8) | 556 | (26.5) | 2.9 |
>1001 mL | 176 | (8.8) | 14 | (9.0) | −1.0 | 190 | (8.8) | 214 | (10.2) | −4.8 |