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Table 3 Analysis of applying best and previously published cut-off points of urinary [TIMP–2]*[IGFBP7] for the prediction of AKI KDIGO 2/3

From: Urinary [TIMP-2]*[IGFBP7] for early prediction of acute kidney injury after coronary artery bypass surgery

AUC Cut-off Sensitivity Specificity
4 h after surgery
 0.861 0.15 0.83 66.7
0.3 0.67 0.76
2.0 0.33 0.98
Day 1 after surgery
 0.817 0.89 0.8 0.81
0.3 1.0 0.07
2.0 0.4 0.95
Maximum early valuea
 0.838 0.89 0.83 0.78
0.3 0.83 0.35
2.0 66.7 0.94
  1. AKI acute kidney injury, AUC area under the curve, IGFBP7 insulin-like growth factor-binding protein 7, KDIGO Kidney Disease: Improving Global Outcomes, RRT renal replacement therapy, TIMP-2 tissue metalloproteinase-2
  2. aDefined as maximum level in the first 24 h after surgery
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