Urinary [TIMP-2]*[IGFBP7] for early prediction of acute kidney injury after coronary artery bypass surgery

Annals of Intensive Care

Table 3 Analysis of applying best and previously published cut-off points of urinary [TIMP–2]*[IGFBP7] for the prediction of AKI KDIGO 2/3

AUC	Cut-off	Sensitivity	Specificity
4 h after surgery
0.861	0.15	0.83	66.7
	0.3	0.67	0.76
	2.0	0.33	0.98
Day 1 after surgery
0.817	0.89	0.8	0.81
	0.3	1.0	0.07
	2.0	0.4	0.95
Maximum early value^a
0.838	0.89	0.83	0.78
	0.3	0.83	0.35
	2.0	66.7	0.94

AKI acute kidney injury, AUC area under the curve, IGFBP7 insulin-like growth factor-binding protein 7, KDIGO Kidney Disease: Improving Global Outcomes, RRT renal replacement therapy, TIMP-2 tissue metalloproteinase-2
^aDefined as maximum level in the first 24 h after surgery