Associations between bolus infusion of hydrocortisone, glycemic variability and insulin infusion rate variability in critically Ill patients under moderate glycemic control

Annals of Intensive Care

Table 4 Results of univariate and multivariate analysis with glycemic variability

Variable	Univariate		Multivariate
Variable	Percentage of change in glycemic variability [95 % CI]	P value	Percentage of change in glycemic variability [95 % CI]	P value
APACHE II score <15
Bolus infusion of hydrocortisone	20 [5 – 36]	0.008	23 [8 – 40]^a	0.0018
APACHE II score 15–24
Bolus infusion of hydrocortisone	22 [16 – 29]	<0.001	23 [16 – 30]^b	< 0.001
APACHE II score >24
Bolus infusion of hydrocortisone	15 [8–21]	<0.001	14 [8–20]^c	< 0.001

APACHE acute physiology and chronic health evaluation, BMI body mass index, CI confidence interval
^aMultivariate model includes the significant confounders Admission Type, and BMI
^bMultivariate model includes the significant confounders Admission Type, gender and BMI
^cMultivariate model includes the significant confounders Admission Type, and gender