Table 3 Drug classes, specific medications associated with D and/or X interactions, and the frequency of interactions
Drug classes (frequency of interactions) | Specific medications (frequency of interactions) |
|---|---|
Anti-infective agents (124) | Itraconazole (24), Ciprofloxacin (17), Voriconazole (16), Rifampin (14), Clarithromycin (11), Erythromycin (10), Dapsone (7), Co-trimoxazole (5), Levofloxacin (4), Posaconazole (4), Meropenem (3), Ofloxacin (3), Isoniazid (2), Pyrazinamide (1), Lamivudine (1), Valganciclovir (1), Caspofungin (1) |
Central nervous system agents (99) | Carbamazepine (20), Phenytoin (16), Fentanyl (11), Midazolam (10), Haloperidol (8), Valproic acid (5), Indomethacin (5), Quetiapine fumarate (4), Citalopram (4), Risperidone (2), Imipramine (2), Clonazepam (2), Methadone (2), Lorazepam (1), Chlorpromazine (1), Celecoxib (1), Diclofenac (1), Fluvoxamine (1), Alprazolam (1), Clomipramine (1), Carbidopa and Levodopa (1) |
Cardiovascular drugs (65) | Atorvastatin (19), Metoprolol (10), Losartan (6), Amiodarone (6), Amlodipine (4), Diltiazem (4), Captopril (3), Sildenafil (2), Carvedilol (2), Furosemide (2), Digoxin (2), Propranolol (1), Dabigatran (1), Heparin (1), Enalapril (1), Gemfibrozil (1) |
Hormones and synthetic substitutes (56) | Dexamethasone (33), Prednisolone (9), Methylprednisolone (6), Levothyroxine (4), Hydrocortisone (3), Octreotide (1) |
Miscellaneous therapeutic agents (35) | Cyclosporine (15), Tacrolimus (10), Mycophenolate (6), Tamsulosin (3), ALLOPURINOL (1) |
Electrolytic, caloric, and water balance (33) | Calcium carbonate (16), Magnesium sulfate (5), Sodium polystyrene sulfate (4), Calcium gluconate (3), Sodium phosphate (2), Spironolactone (1), Zinc sulfate (1), Potassium chloride (1) |
Gastrointestinal drugs (33) | Pantoprazole (19), Granisetron (8), Ranitidine (3), Metoclopramide (1), Omeprazole (1), Aluminum, Magnesium hydroxide (1) |
Blood formation, coagulation, and thrombosis (17) | Warfarin (6), Clopidogrel (4), Ferrous sulfate (4), Acetylsalicylic acid (3) |
Respiratory tract agents (16) | Ipratropium (7), Formoterol (3), Fluticasone (3), Salbutamol (2), Theophylline (1) |
Autonomic drugs (15) | Atracurium (9), Tizanidine (2), Prazosin (2), Cisatracurium (1), Epinephrine (1) |
Vitamins (3) | Calcitriol (3) |