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Table 3 Drug classes, specific medications associated with D and/or X interactions, and the frequency of interactions

From: Important drug classes associated with potential drug–drug interactions in critically ill patients: highlights for cardiothoracic intensivists

Drug classes (frequency of interactions) Specific medications (frequency of interactions)
Anti-infective agents (124) Itraconazole (24), Ciprofloxacin (17), Voriconazole (16), Rifampin (14), Clarithromycin (11), Erythromycin (10), Dapsone (7), Co-trimoxazole (5), Levofloxacin (4), Posaconazole (4), Meropenem (3), Ofloxacin (3), Isoniazid (2), Pyrazinamide (1), Lamivudine (1), Valganciclovir (1), Caspofungin (1)
Central nervous system agents (99) Carbamazepine (20), Phenytoin (16), Fentanyl (11), Midazolam (10), Haloperidol (8), Valproic acid (5), Indomethacin (5), Quetiapine fumarate (4), Citalopram (4), Risperidone (2), Imipramine (2), Clonazepam (2), Methadone (2), Lorazepam (1), Chlorpromazine (1), Celecoxib (1), Diclofenac (1), Fluvoxamine (1), Alprazolam (1), Clomipramine (1), Carbidopa and Levodopa (1)
Cardiovascular drugs (65) Atorvastatin (19), Metoprolol (10), Losartan (6), Amiodarone (6), Amlodipine (4), Diltiazem (4), Captopril (3), Sildenafil (2), Carvedilol (2), Furosemide (2), Digoxin (2), Propranolol (1), Dabigatran (1), Heparin (1), Enalapril (1), Gemfibrozil (1)
Hormones and synthetic substitutes (56) Dexamethasone (33), Prednisolone (9), Methylprednisolone (6), Levothyroxine (4), Hydrocortisone (3), Octreotide (1)
Miscellaneous therapeutic agents (35) Cyclosporine (15), Tacrolimus (10), Mycophenolate (6), Tamsulosin (3), ALLOPURINOL (1)
Electrolytic, caloric, and water balance (33) Calcium carbonate (16), Magnesium sulfate (5), Sodium polystyrene sulfate (4), Calcium gluconate (3), Sodium phosphate (2), Spironolactone (1), Zinc sulfate (1), Potassium chloride (1)
Gastrointestinal drugs (33) Pantoprazole (19), Granisetron (8), Ranitidine (3), Metoclopramide (1), Omeprazole (1), Aluminum, Magnesium hydroxide (1)
Blood formation, coagulation, and thrombosis (17) Warfarin (6), Clopidogrel (4), Ferrous sulfate (4), Acetylsalicylic acid (3)
Respiratory tract agents (16) Ipratropium (7), Formoterol (3), Fluticasone (3), Salbutamol (2), Theophylline (1)
Autonomic drugs (15) Atracurium (9), Tizanidine (2), Prazosin (2), Cisatracurium (1), Epinephrine (1)
Vitamins (3) Calcitriol (3)