|
Anti-infective agents
|
Itraconazole
|
Tacrolimus
|
Metabolism (inh)
|
Monitor tacrolimus concentration
|
|
Diltiazem
|
Metabolism (inh)
|
Monitor diltiazem toxic effects
|
|
Digoxin
|
Absorption
|
Monitor digoxin concentration
|
|
Atorvastatin
|
Metabolism (inh)
|
Reduce dose, monitor toxic effects
|
|
Clarithromycin
|
Metabolism (inh)b
|
Monitor toxic effect of clarithromycin/itraconazole
|
|
Methylprednisolone
|
Metabolism (inh)
|
Reduce dose, monitor corticosteroid toxicity
|
|
Voriconazole
|
Tacrolimus
|
Metabolism (inh)
|
Reduce dose, monitor tacrolimus concentration
|
|
Cyclosporine
|
Metabolism (inh)
|
Reduce dose, monitor cyclosporine concentration
|
|
Diltiazem
|
Metabolism (inh)
|
Monitor diltiazem toxic effects
|
|
Methylprednisolone
|
Metabolism (inh)
|
Reduce dose, monitor corticosteroid toxicity
|
|
Methadone
|
Metabolism (inh)
|
Monitor methadone toxic effects
|
|
Midazolam
|
Metabolism (inh)
|
Monitor midazolam toxic effects
|
|
Ciprofloxacin
|
Theophylline
|
Metabolism (inh)
|
Reduce dose, monitor theophylline toxic effects
|
|
Erythromycin
|
Additive
|
Avoid combination
|
|
Formoterol
|
Additive
|
Avoid combination
|
|
Granisetron
|
Additive
|
Avoid combination
|
|
Voriconazole
|
Additive
|
Avoid combination
|
| |
Rifampin
|
Itraconazole
|
Metabolism (ind/inh)b
|
Avoid combination/monitor for clinical response to itraconazole
|
|
Clarithromycin
|
Metabolism (ind/inh)b
|
Monitor for clarithromycin therapeutic effects/rifampin toxic effects
|
|
Cyclosporine
|
Metabolism (ind)
|
Consider an alternative, monitor cyclosporine serum concentrations
|
|
Midazolam
|
Metabolism (ind)
|
Monitor midazolam therapeutic effects
|
|
Dapsone
|
Metabolism (ind)
|
Monitor for dapsone therapeutic effects and methemoglobinemia
|
|
Erythromycin
|
Amlodipine
|
Metabolism (inh)
|
Consider an alternative, monitor toxic effects
|
|
Carbamazepine
|
Metabolism (inh)
|
Consider an alternative, monitor toxic effects
|
|
Dexamethasone
|
Metabolism (inh)
|
Monitor corticosteroids toxic effects
|
|
Prednisolone
|
Metabolism (inh)
|
Monitor corticosteroids toxic effects
|
|
Posaconazole
|
Midazolam
|
Metabolism (inh)
|
Consider an alternative, monitor toxic effects
|
|
Isoniazid
|
Metoprolol
|
Metabolism (inh)
|
Consider an alternative, monitor response
|
|
Valganciclovir
|
Lamivudine
|
Additive
|
Monitor hematologic toxicity
|
|
Clarithromycin
|
Midazolam
|
Metabolism (inh)
|
Consider an alternative, monitor for toxic effects
|
|
Central nervous system agents
|
Carbamazepine
|
Phenytoin
|
Metabolism (ind)b
|
Monitor for phenytoin/carbamazepine serum concentrations
|
|
Clonazepam
|
Metabolism (ind)
|
Consider an alternative
|
|
Warfarin
|
Metabolism (ind)
|
Monitor therapeutic effects
|
|
Citalopram
|
Metabolism (ind/inh)b
|
Monitor citalopram therapeutic effects/carbamazepine toxic effects
|
|
Fluvoxamine
|
Metabolism (ind/inh)b
|
Monitor fluvoxamine therapeutic effects/carbamazepine toxic effects
|
| |
Imipramine
|
Metoprolol
|
Metabolism (inh)
|
Consider an alternative, monitor response
|
|
Citalopram
|
Metabolism (inh)b
|
Consider an alternative, monitor toxic effects of imipramine/citalopram
|
|
Quetiapine fumarate
|
Haloperidol
|
Additive
|
Avoid combination
|
|
Carbidopa and levodopa
|
Antagonistic
|
Consider an alternative
|
|
Phenytoin
|
Amlodipine
|
Metabolism (ind/inh)b
|
Monitor amlodipine therapeutic effects/phenytoin toxicity
|
|
Indomethacin
|
Acetylsalicylic acid
|
Additive
|
Monitor bleeding, avoid regular use of indomethacin
|
|
Cyclosporine
|
Additive
|
Consider an alternative, monitor nephrotoxicity
|
|
Furosemide
|
Antagonistic
|
Monitor therapeutic effect
|
|
Valproic acid
|
Lorazpam
|
Metabolism (inh)
|
Monitor lorazepam toxic effects
|
|
Electrolytic, caloric, and water balance
|
Sodium polystyrene sulfate
|
Calcium carbonate
|
Antagonistic
|
Separate doses by 2 or more hours, monitor metabolic alkalosis
|
|
Zinc sulfate
|
Ofloxacin
|
Absorption
|
Separate doses by 2 or more hours
|
|
Magnesium sulfate
|
Ciprofloxacin
|
Absorption
|
Separate doses by 2 or more hours
|
|
Calcium carbonate
|
Isoniazid
|
Absorption
|
Separate doses by 2 or more hours
|
|
Levofloxacin
|
Absorption
|
Separate doses by 2 or more hours
|
|
Mycophenolate
|
Absorption
|
Separate doses by 2 or more hours
|
|
Autonomic drugs
|
Atracurium
|
Methylprednisolone
|
Additive
|
Monitor neuromuscular adverse effects
|
|
Prednisolone
|
Additive
|
Monitor neuromuscular adverse effects
|
|
Dexamethasone
|
Additive
|
Monitor neuromuscular adverse effects
|
|
Hydrocortisone
|
Additive
|
Monitor neuromuscular adverse effects
|
|
Cisatracurium
|
Prednisolone
|
Additive
|
Monitor neuromuscular adverse effects
|
|
Cardiovascular drugs
|
Amiodarone
|
Digoxin
|
Excretion
|
Reduce digoxin dosage, monitor serum concentration
|
|
Metoprolol
|
Metabolism (inh)
|
Consider an alternative, monitor response
|
|
Gemfibrozil
|
Atorvastatin
|
Metabolism (inh)
|
Avoid combination
|
|
Metoprolol
|
Epinephrine
|
Additive
|
Monitor pressor effects of epinephrine
|
|
Blood formation, coagulation, ……
|
Acetylsalicylic acid
|
Warfarin
|
Additive
|
Monitor bleeding
|
|
Ferrous sulfate
|
Ofloxacin
|
Absorption
|
Separate doses by 4 or more hours
|
|
Levothyroxine
|
Absorption
|
Separate doses by 2 or more hours
|
|
Gastrointestinal drugs
|
Pantoprazole
|
Itraconazole
|
Absorption
|
Administer itraconazole with an acidic beverage, monitor response
|
|
Ranitidine
|
Itraconazole
|
Absorption
|
Administer itraconazole with an acidic beverage, monitor response
|
|
Hormones and synthetic substitutes
|
Dexamethasone
|
Clarithromycin
|
Metabolism (ind/inh)b
|
Consider alternative antimicrobial therapy/monitor for dexamethasone toxic effects
|
|
Itraconazole
|
Metabolism (ind)
|
Avoid combination, monitor for therapeutic effects
|
|
Miscellaneous
|
Cyclosporine
|
Atorvastatin
|
Metabolism (inh)
|
Avoid combination
|
|
Mycophenolate
|
Excretion
|
Monitor mycophenolate dosing and response to therapy
|
