Table 3 Changes in electrolytes, hemodynamic, and biochemistry parameters before and after administration of Tolvaptan

Serum sodium concentration (mmol/l)

133 [132; 135]

138 [137; 141]

Urine sodium concentration (mmol/l)

123.2 ± 36.5

54.9 ± 5.4

Serum potassium concentration (mmol/l)

4.1 ± 0.4

4.2 ± 0.3

Urine potassium concentration (mmol/l)

32.2 ± 16.8

24.8 ± 15.1

Urine output (ml/24 h)

2149 ± 966

3593 ± 1673

Sodium input (mmol/24 h)

159 [111; 214]

148 [115; 169]

Sodium balance (mmol/24 h)

−69 [143; 20]

−49 [−146; 37]

Sodium output (mmol/24 h)

236.5 [120; 311]

190.5 [119.5; 298.5]

Sodium-free water clearance (%)

9.6 [−12.0; 24.4]

59.9 [43.3; 76.6]

Fluid balance (ml/24 h)

−200 [−950; 0]

−1300 [−2200; −550]

Heart rate (1/min)

90.3 ± 18.2

92.1 ± 20.4

Mean arterial pressure (mmHg)

84.3 ± 13.9

82.7 ± 11.0

Central venous pressure (mmHg)

7.1 ± 3.6

6.1 ± 4.1

Patients on vasopressors

1/38

1/38

Central venous oxygen saturation (%)

71.6 ± 7.4

70.9 ± 7.2

Albumin concentration (g/100 ml)

2.3 ± 0.3

2.6 ± 0.3

Hemoglobin concentration (g/100 ml)

10.6 ± 2.0

10.8 ± 2.0

Aspartate aminotransferase (IU/l)

59 ± 27

49 ± 22

Alanine aminotransferase (IU/l)

84 ± 55

80 ± 56

Bilirubin concentration (mg/100 ml)

1.8 ± 1.3

1.9 ± 1

Serum creatinine concentration (mg/100 ml)

0.9 ± 0.6

0.8 ± 0.5

Blood urea nitrogen (mg/100 ml)

23.6 ± 13.3

20.1 ± 11.5

Serum lactate concentration (mmol/l)

1.2 ± 0.7

1.0 ± 0.4

Serum glucose concentration (mg/100 ml)

126 ± 28

120 ± 21