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Table 1 Characteristics of patients with initially proven and suspected invasive candidiasis

From: Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study

Patients’ characteristics SAT for initially proven invasive candidiasis
N = 291
SAT for suspected invasive candidiasis
N = 544
P value
At ICU admission    
 Age (years) 62.2 ± 15.4 61.9 ± 14.5 0.93
 Male gender 185 (63.6) 337 (62.0) 0.64
Reason for admission to ICU
 Medical 119 (40.9) 268 (49.3) 0.02
 Surgical 161 (55.3) 260 (47.8) 0.04
 Trauma 16 (5.5) 16 (2.9) 0.08
C-reactive protein (mg/L) 165.9 ± 109.4 173.1 ± 122.6 0.67
Creatinine (µmol/L) 145.8 ± 109.6 132.1 ± 96.9 0.13
Red blood cell transfusion in ICU 163 (56.0) 289 (53.1) 0.42
Platelet transfusion in ICU 60 (20.6) 119 (21.9) 0.67
At SAT initiation
 Length of hospital stay before SAT (days) 13 [6; 23] 11 [4; 20] <0.01
 Length of ICU stay before SAT (days) 5 [2; 14] 4 [0; 11] <0.01
 Body temperature (°C) 37.6 ± 1.3 37.7 ± 1.3 0.34
 SAPS II 46.2 ± 18.0 50.1 ± 18.7 0.006
 SOFA score 7.3 ± 4.8 8.3 ± 4.3 0.0007
 Septic shock 120 (41.2) 330 (66.7) <0.0001
 Severe sepsis 118 (40.6) 203 (37.3) 0.36
Risk factors for invasive candidiasisa
 Invasive mechanical ventilation 196 (67.4) 458 (84.2) <0.0001
 Central venous catheter 278 (95.5) 526 (96.7) 0.44
 Urinary catheterization 280 (96.2) 516 (94.9) 0.50
 Antibiotic treatment 268 (92.1) 481 (88.4) 0.12
 Total parenteral nutrition 149 (51.2) 235 (43.2) 0.03
 Hemodialysis or hemodiafiltration 92 (31.6) 160 (29.4) 0.51
 Corticosteroid treatment 55 (18.9) 151 (27.8) 0.005
Surgery just before or during ICU stay 197 (67.7) 341 (62.7) 0.15
 Abdominal surgery 156 (78.2) 263 (79.2) 0.80
 Scheduled abdominal surgery 16 (10.3) 48 (18.3) 0.03
 Emergency abdominal surgery 140 (89.7) 215 (81.7) 0.03
 Mortality on D28 96 (34.4 %) 163 (31.6 %) 0.42
  1. The results are given as n (%) or mean ± SD, when indicated
  2. SAT systemic antifungal therapy, ICU intensive care unit, SOFA sequential organ failure assessment; SAPS II: simplified acute physiology score
  3. aRisk factors as per IDSA and ESCMID guidelines (3, 4)