Table 5 Factors associated with 28-day mortality in patients with proven IC
From: Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study
Patients’ characteristics | Survivors (N = 273) | Non survivors (N = 130) | P value |
|---|---|---|---|
At ICU admission | |||
Age | 61.5 [51; 70.1] | 66.5 [57.9; 78.8] | <.01 |
Male gender | 171 (62.6) | 83 (63.8) | 0.81 |
SAPSII | 42 [30; 52] | 56 [45; 67] | <0.01 |
SOFA score | 8 [5; 10] | 9.5 [7; 13] | <0.01 |
Immunosuppression | 29 (10.6) | 31 (23.8) | <0.01 |
Reason for admission to ICU | <0.01 | ||
Medical | 88 (32.2) | 66 (50.8) | |
Elective surgical | 24 (8.8) | 14 (10.8) | |
Emergency surgical | 144 (52.7) | 48 (36.9) | |
Trauma | 17 (6.2) | 2 (1.5) | |
Red blood cell transfusion in ICU | 141 (51.6) | 79 (60.8) | 0.09 |
Platelet transfusion in ICU | 49 (17.9) | 36 (27.7) | 0.03 |
At SAT initiation | |||
Body temperature (°C) | 38 [37; 38.5] | 37.6 [36.9; 38.2] | <0.01 |
SOFA score | 6 [3; 9] | 9 [6; 13] | <0.01 |
Septic shock | 110 (40.3) | 72 (55.4) | <0.01 |
Severe sepsis | 117 (42.9) | 48 (36.9) | 0.26 |
Invasive mechanical ventilation | 191 (70) | 97 (74.6) | 0.33 |
Central venous catheter | 261 (95.6) | 126 (96.9) | 0.53 |
Urinary catheterization | 259 (94.9) | 129 (99.2) | 0.03 |
Hemodialysis or hemodiafiltration | 68 (24.9) | 53 (40.8) | <0.01 |
Total parenteral nutrition | 135 (49.5) | 64 (49.2) | 0.97 |
Corticosteroid treatment | 44 (16.1) | 38 (29.2) | <0.01 |
Surgery just before or during ICU stay | 209 (76.6) | 75 (57.7) | <0.01 |
Initial SAT | 0.26 | ||
Amphotericin B | 4 (1.5) | 2 (1.5) | |
Fluconazole | 112 (41) | 40 (30.8) | |
Voriconazole | 2 (0.7) | 1 (0.8) | |
Echinocandins | 155 (56.8) | 87 (66.9) | |
SAT instituted before the knowledge of positive sample | 0.14 | ||
No | 191 (70) | 100 (76.9) | |
Yes | 82 (30) | 30 (23.1) |