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Table 2 Illness severity, organ function and inflammatory response at study inclusion

From: Plasma endostatin may improve acute kidney injury risk prediction in critically ill patients

  No AKI (n = 72) AKI (n = 21) P value
Vasopressors and inotropes    
 Noradrenaline dose (µg/kg/min) 0 (0, 0.03) 0.01 (0, 0.04) 0.43
 Adrenaline [n (%)] 0 (0) 1 (4.8 %) 0.23
 Dobutamine [n (%)] 1 (1.4 %) 3 (14.3 %) 0.04
Kidney function    
 Plasma creatinine [µmol/l] 82 (69, 96) 91 (74, 93) 0.20
 Δ creatinine [%] 0 (−12, 18) 8 (1, 25) 0.07
 Early oliguriaa [n (%)] 6 (8.3 %) 9 (42.9 %) 0.001
 Furosemide dose, mg during previous 24 h 6 (0, 23) 0 (0, 35) 0.93
Lung function    
 Mechanical ventilation [n (%)] 56 (77.8 %) 16 (76.2 %) 1.0
 FiO2 0.35 (0.26, 0.47) 0.40 (0.30, 0.50) 0.15
 PaO2 (kPa) 10 (9, 11) 10 (9, 11) 0.95
 PaO2/FiO2 ratio 29 (20, 42) 26 (18, 35) 0.31
 PaCO2 (kPa) 4.8 (4.3, 5.4) 4.5 (4.3, 5.0) 0.12
Metabolic    
 pH 7.4 (7.3, 7.4) 7.4 (7.3, 7.4) 0.64
 Base excess (mmol/L) 0.2 (−2.4, 2.8) −0.3 (−4.1, 1.0) 0.18
 Lactate (mmol/L) 1.6 (1.2, 2.6) 2.1 (1.2, 2.8) 0.50
Inflammatory response    
 SIRS [n (%)] 52 (72.2 %) 14 (66.7 %) 0.60
 SIRS + suspected or confirmed infection [n (%)] 38 (52.8 %) 13 (61.9 %) 0.62
 White cell count (×109/L) 11 (8, 15) 10 (8, 13) 0.45
 C-reactive protein (mg/dL) 74 (26, 181) 45 (15, 193) 0.56
Plasma biomarkers levels on inclusion    
 Endostatin (ng/mL) 31 (23, 40) 42 (35, 54) 0.002
 Cystatin C (mg/dL) 0.75 (0.64, 1.00) 1.10 (0.82, 1.40) 0.02
 NGAL (ng/mL) 97 (66, 149) 133 (67, 180) 0.29
  1. Values are reported as median (interquartile range) or as n (%)
  2. aUrine output <0.5 mL/kg/h during >2 h but <6 h