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Table 2 Drug history before intensive care unit admission

From: An observational study of adult admissions to a medical ICU due to adverse drug events

Characteristics Total (n = 743) Preventable ADE (n = 102) Unpreventable ADE (n = 71) Control (n = 570) P value
Preventable–unpreventable Preventable–control Unpreventable–control
Number of drugs taken >1 month before ICU admission (median [IQR]) 5 [2; 8] 5 [3; 8] 6 [4; 9] 5 [2; 8] 0.17 0.15 4.3 × 10−3
Number of drugs taken < 1 month before ICU admission (median [IQR]) 3 [1; 5] 4 [1; 7] 8 [4; 12] 2 [0; 4] 6.0 × 10−6 1.6 × 10−4 2.2 × 10−16
Total number of drugs taken before ICU admission (median [IQR]) 9 [5; 13] 11 [7; 15] 15 [12; 20] 8 [4; 11] 8.5 × 10−7 3.1 × 10−5 2.2 × 10−16
Number of drugs involved in the ADEa [n (%)]      0.19 NA NA
 1 NA 33 (57 %) 29 (41 %) NA    
 2 NA 15 (26 %) 24 (34 %) NA    
 ≥3 NA 10 (17 %) 18 (25 %) NA    
Origin of prescriptions, n (%)      2.2 × 10−16 NA NA
 Hospital NA 30 (29 %) 59 (83 %) NA    
 Community NA 19 (19 %) 12 (17 %) NA    
 Otherb NA 53 (52 %) 0 (0 %) NA    
  1. ADE adverse drug event, ICU intensive care unit, IQR inter-quartile range, NA non-applicable
  2. aAdmissions due to non-compliance or drug underuse were excluded from the analysis (44 admissions in the preventable group) in the analysis of the item “number of drugs involved”
  3. bAdmissions due to self-medication, compliance problems or drug underuse