Table 4 Treatments and outcomes of intensive care unit admissions
From: An observational study of adult admissions to a medical ICU due to adverse drug events
Characteristics | Total (n = 743) | Preventable ADE (n = 102) | Unpreventable ADE (n = 71) | Control (n = 570) | P value | ||
|---|---|---|---|---|---|---|---|
Preventable–unpreventable | Preventable–control | Unpreventable–control | |||||
Number of organ support(s) [n (%)] | 0.34 | 0.37 | 0.28 | ||||
0 | 312 (42 %) | 48 (47 %) | 25 (35 %) | 239 (42 %) | |||
1 | 232 (31 %) | 31 (30 %) | 22 (31 %) | 179 (31 %) | |||
2 | 128 (17 %) | 12 (12 %) | 13 (18 %) | 103 (18 %) | |||
≥3 | 71 (10 %) | 11 (11 %) | 11 (16 %) | 49 (9 %) | |||
Type of organ support [n (%)] | |||||||
Noninvasive ventilation | 115 (15 %) | 10 (10 %) | 8 (11 %) | 97 (17 %) | 0.80 | 7.7 × 10−2 | 0.30 |
Invasive ventilation | 270 (36 %) | 30 (29 %) | 29 (41 %) | 211 (37 %) | 0.14 | 0.15 | 0.52 |
Catecholamine | 237 (32 %) | 27 (26 %) | 33 (46 %) | 177 (31 %) | 9.1 × 10−3 | 0.41 | 0.11 |
Renal replacement therapy | 70 (9 %) | 16 (16 %) | 10 (14 %) | 44 (8 %) | 0.83 | 1.4 × 10−2 | 0.11 |
Massive blood transfusion (>1/2 blood volume) | 26 (3 %) | 7 (7 %) | 6 (8 %) | 13 (2 %) | 0.77 | 2.1 × 10−2 | 1.3 × 10−2 |
Mortality during ICU admission [n (%)]a | 125 (17 %) | 14 (14 %) | 18 (25 %) | 93 (16 %) | 7.2 × 10−2 | 0.56 | 6.7 × 10−2 |
Mortality during hospital admission[n (%)]a | 161 (22 %) | 17 (17 %) | 25 (35 %) | 119 (21 %) | 6.7 × 10−3 | 0.42 | 9.8 × 10−3 |
Length of ICU stay (median [IQR]) | 4 [2; 7] | 4 [2; 7] | 4 [2; 9] | 4 [2; 7] | 0.15 | 0.49 | 0.26 |
Length of hospital stay (median [IQR]) | 13 [6; 29] | 13 [5; 28] | 23 [9; 48] | 12 [5; 28] | 5.4 × 10−3 | 0.47 | 1.2 × 10−4 |
Estimated costs (euros)of ICU admissions (median [IQR]) | 4651[2382; 10,298] | 3688 [2562; 8705] | 5802 [2425; 13,460] | 4694 [2 342; 10 301] | 7.4 × 10−2 | 0.52 | 0.11 |
Estimated costs (euros)of hospital admissions (median [IQR]) | 10,623 [5889; 18,698] | 9015 [5823; 18,043] | 13,933 [8429; 37,047] | 10,204 [5749; 17,248] | 8.5 × 10−4 | 0.97 | 5.2 × 10−5 |