Skip to main content

Table 4 Treatments and outcomes of intensive care unit admissions

From: An observational study of adult admissions to a medical ICU due to adverse drug events

Characteristics Total (n = 743) Preventable ADE (n = 102) Unpreventable ADE (n = 71) Control (n = 570) P value
Preventable–unpreventable Preventable–control Unpreventable–control
Number of organ support(s) [n (%)]      0.34 0.37 0.28
 0 312 (42 %) 48 (47 %) 25 (35 %) 239 (42 %)    
 1 232 (31 %) 31 (30 %) 22 (31 %) 179 (31 %)    
 2 128 (17 %) 12 (12 %) 13 (18 %) 103 (18 %)    
 ≥3 71 (10 %) 11 (11 %) 11 (16 %) 49 (9 %)    
Type of organ support [n (%)]        
 Noninvasive ventilation 115 (15 %) 10 (10 %) 8 (11 %) 97 (17 %) 0.80 7.7 × 10−2 0.30
 Invasive ventilation 270 (36 %) 30 (29 %) 29 (41 %) 211 (37 %) 0.14 0.15 0.52
 Catecholamine 237 (32 %) 27 (26 %) 33 (46 %) 177 (31 %) 9.1 × 10−3 0.41 0.11
 Renal replacement therapy 70 (9 %) 16 (16 %) 10 (14 %) 44 (8 %) 0.83 1.4 × 10−2 0.11
 Massive blood transfusion (>1/2 blood volume) 26 (3 %) 7 (7 %) 6 (8 %) 13 (2 %) 0.77 2.1 × 10−2 1.3 × 10−2
Mortality during ICU admission [n (%)]a 125 (17 %) 14 (14 %) 18 (25 %) 93 (16 %) 7.2 × 10−2 0.56 6.7 × 10−2
Mortality during hospital admission[n (%)]a 161 (22 %) 17 (17 %) 25 (35 %) 119 (21 %) 6.7 × 10−3 0.42 9.8 × 10−3
Length of ICU stay (median [IQR]) 4 [2; 7] 4 [2; 7] 4 [2; 9] 4 [2; 7] 0.15 0.49 0.26
Length of hospital stay (median [IQR]) 13 [6; 29] 13 [5; 28] 23 [9; 48] 12 [5; 28] 5.4 × 10−3 0.47 1.2 × 10−4
Estimated costs (euros)of ICU admissions (median [IQR]) 4651[2382; 10,298] 3688 [2562; 8705] 5802 [2425; 13,460] 4694 [2 342; 10 301] 7.4 × 10−2 0.52 0.11
Estimated costs (euros)of hospital admissions (median [IQR]) 10,623 [5889; 18,698] 9015 [5823; 18,043] 13,933 [8429; 37,047] 10,204 [5749; 17,248] 8.5 × 10−4 0.97 5.2 × 10−5
  1. ADE adverse drug event, ICU intensive care unit, IQR inter-quartile range
  2. aPercentage of mortality based on the number of admissions