TY - JOUR AU - Sterling, S. A. AU - Puskarich, M. A. AU - Shapiro, N. I. AU - Trzeciak, S. AU - Kline, J. A. AU - Summers, R. L. PY - 2013 DA - 2013// TI - Characteristics and outcomes of patients with vasoplegic versus tissue dysoxic septic shock JO - Shock VL - 40 UR - https://doi.org/10.1097/SHK.0b013e318298836d DO - 10.1097/SHK.0b013e318298836d ID - Sterling2013 ER - TY - JOUR AU - Dellinger, R. P. AU - Levy, M. M. AU - Rhodes, A. AU - Annane, D. AU - Gerlach, H. AU - Opal, S. M. PY - 2013 DA - 2013// TI - Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012 JO - Crit Care Med VL - 41 UR - https://doi.org/10.1097/CCM.0b013e31827e83af DO - 10.1097/CCM.0b013e31827e83af ID - Dellinger2013 ER - TY - JOUR AU - James, J. H. AU - Luchette, F. A. AU - McCarter, F. D. AU - Fischer, J. E. PY - 1999 DA - 1999// TI - Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis JO - Lancet VL - 354 UR - https://doi.org/10.1016/S0140-6736(98)91132-1 DO - 10.1016/S0140-6736(98)91132-1 ID - James1999 ER - TY - JOUR AU - Garcia-Alvarez, M. AU - Marik, P. AU - Bellomo, R. PY - 2014 DA - 2014// TI - Sepsis-associated hyperlactatemia JO - Crit Care VL - 18 UR - https://doi.org/10.1186/s13054-014-0503-3 DO - 10.1186/s13054-014-0503-3 ID - Garcia-Alvarez2014 ER - TY - JOUR AU - Beest, P. AU - Wietasch, G. AU - Scheeren, T. AU - Spronk, P. AU - Kuiper, M. PY - 2011 DA - 2011// TI - Clinical review: use of venous oxygen saturations as a goal—a yet unfinished puzzle JO - Crit Care VL - 15 UR - https://doi.org/10.1186/cc10351 DO - 10.1186/cc10351 ID - Beest2011 ER - TY - JOUR AU - Squara, P. PY - 2014 DA - 2014// TI - Central venous oxygenation: when physiology explains apparent discrepancies JO - Crit Care VL - 18 UR - https://doi.org/10.1186/s13054-014-0579-9 DO - 10.1186/s13054-014-0579-9 ID - Squara2014 ER - TY - JOUR AU - Mekontso-Dessap, A. AU - Castelain, V. AU - Anguel, N. AU - Bahloul, M. AU - Schauvliege, F. AU - Richard, C. PY - 2002 DA - 2002// TI - Combination of venoarterial PCO2 difference with the arteriovenous O2 content difference to detect anaerobic metabolism in patients JO - Intensive Care Med VL - 28 UR - https://doi.org/10.1007/s00134-002-1215-8 DO - 10.1007/s00134-002-1215-8 ID - Mekontso-Dessap2002 ER - TY - JOUR AU - Monnet, X. AU - Julien, F. AU - Ait-Hamou, N. AU - Lequoy, M. AU - Gosset, C. AU - Jozwiak, M. PY - 2013 DA - 2013// TI - Lactate and venoarterial carbon dioxide difference/arterial–venous oxygen difference ratio, but not central venous oxygen saturation, predict increase in oxygen consumption in fluid responders JO - Crit Care Med VL - 41 UR - https://doi.org/10.1097/CCM.0b013e318275cece DO - 10.1097/CCM.0b013e318275cece ID - Monnet2013 ER - TY - JOUR AU - Levy, M. M. AU - Fink, M. P. AU - Marshall, J. C. AU - Abraham, E. AU - Angus, D. AU - Cook, D. PY - 2003 DA - 2003// TI - 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference JO - Intensive Care Med VL - 29 UR - https://doi.org/10.1007/s00134-003-1662-x DO - 10.1007/s00134-003-1662-x ID - Levy2003 ER - TY - JOUR AU - Douglas, A. R. AU - Jones, N. L. AU - Reed, J. W. PY - 1998 DA - 1998// TI - Calculation of whole blood CO2 content JO - J Appl Physiol VL - 65 ID - Douglas1998 ER - TY - JOUR AU - DeLong, E. R. AU - DeLong, D. M. AU - Clarke-Pearson, D. L. PY - 1988 DA - 1988// TI - Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach JO - Biometrics VL - 44 UR - https://doi.org/10.2307/2531595 DO - 10.2307/2531595 ID - DeLong1988 ER - TY - JOUR AU - Ray, P. AU - Manach, Y. AU - Riou, B. AU - Houle, T. T. PY - 2010 DA - 2010// TI - Statistical evaluation of a biomarker JO - Anesthesiology VL - 112 UR - https://doi.org/10.1097/ALN.0b013e3181d47604 DO - 10.1097/ALN.0b013e3181d47604 ID - Ray2010 ER - TY - JOUR AU - Cain, S. M. AU - Adams, R. P. PY - 1965 DA - 1965// TI - Appearance of excess lactate in anesthetized dogs during anemic and hypoxic hypoxia JO - Am J Physiol VL - 209 ID - Cain1965 ER - TY - JOUR AU - Schumacker, P. T. AU - Cain, S. M. PY - 1987 DA - 1987// TI - The concept of a critical oxygen delivery JO - Intensive Care Med VL - 13 UR - https://doi.org/10.1007/BF00265110 DO - 10.1007/BF00265110 ID - Schumacker1987 ER - TY - JOUR AU - Vincent, J. L. AU - Roman, A. AU - Backer, D. AU - Kahn, R. J. PY - 1990 DA - 1990// TI - Oxygen uptake/supply dependency: effects of short-term dobutamine infusion JO - Am J Respir Crit Care Med VL - 142 ID - Vincent1990 ER - TY - JOUR AU - Friedman, G. AU - Backer, D. AU - Shahla, M. AU - Vincent, J. L. PY - 1998 DA - 1998// TI - Oxygen supply dependency can characterize septic shock JO - Intensive Care Med VL - 24 UR - https://doi.org/10.1007/s001340050531 DO - 10.1007/s001340050531 ID - Friedman1998 ER - TY - JOUR AU - Granton, J. T. AU - Walley, K. R. AU - Phang, P. T. AU - Russell, J. A. AU - Lichtenstein, S. PY - 1998 DA - 1998// TI - Assessment of three methods to reduce the influence of mathematical coupling on oxygen consumption and delivery relationships JO - Chest VL - 113 UR - https://doi.org/10.1378/chest.113.5.1347 DO - 10.1378/chest.113.5.1347 ID - Granton1998 ER - TY - JOUR AU - Hanique, G. AU - Dugernier, T. AU - Laterre, P. F. AU - Dougnac, A. AU - Roeseler, J. AU - Reynaert, M. S. PY - 1994 DA - 1994// TI - Significance of pathologic oxygen supply dependency in critically ill patients: comparison between measured and calculated methods JO - Intensive Care Med VL - 20 UR - https://doi.org/10.1007/BF02425048 DO - 10.1007/BF02425048 ID - Hanique1994 ER - TY - JOUR AU - McCord, J. PY - 1985 DA - 1985// TI - Oxygen-derived free radicals in post ischemic tissue injury JO - N Engl J Med VL - 312 UR - https://doi.org/10.1056/NEJM198501173120305 DO - 10.1056/NEJM198501173120305 ID - McCord1985 ER - TY - JOUR AU - Backer, D. AU - Moraine, J. J. AU - Berre, J. AU - Kahn, R. J. AU - Vincent, J. L. PY - 1994 DA - 1994// TI - Effects of dobutamine on oxygen consumption in septic patients. Direct versus indirect determinations JO - Am J Respir Crit Care Med VL - 150 UR - https://doi.org/10.1164/ajrccm.150.1.8025780 DO - 10.1164/ajrccm.150.1.8025780 ID - Backer1994 ER - TY - JOUR AU - Groeneveld, A. B. AU - Vermeij, C. G. AU - Thijs, L. G. PY - 1991 DA - 1991// TI - Arterial and mixed venous blood acid-base balance during hypoperfusion with incremental positive end-expiratory pressure in the pig JO - Anesth Analg VL - 73 ID - Groeneveld1991 ER - TY - JOUR AU - Cohen, I. L. AU - Sheikh, F. M. AU - Perkins, R. J. AU - Feustel, P. J. AU - Foster, E. D. PY - 1995 DA - 1995// TI - Effect of hemorrhagic shock and reperfusion on the respiratory quotient in swine JO - Crit Care Med VL - 23 UR - https://doi.org/10.1097/00003246-199503000-00021 DO - 10.1097/00003246-199503000-00021 ID - Cohen1995 ER - TY - JOUR AU - Vallet, B. AU - Teboul, J. L. AU - Cain, S. AU - Curtis, S. PY - 2000 DA - 2000// TI - Venoarterial CO(2) difference during regional ischemic or hypoxic hypoxia JO - J Appl Physiol VL - 89 ID - Vallet2000 ER - TY - JOUR AU - Cavaliere, F. AU - Giovannini, I. AU - Chiarla, C. AU - Conti, G. AU - Pennisi, M. A. AU - Montini, L. PY - 2005 DA - 2005// TI - Comparison of two methods to assess blood CO2 equilibration curve in mechanically ventilated patients JO - Respir Physiol Neurobiol VL - 146 UR - https://doi.org/10.1016/j.resp.2004.11.008 DO - 10.1016/j.resp.2004.11.008 ID - Cavaliere2005 ER - TY - JOUR AU - Mchardy, G. J. PY - 1967 DA - 1967// TI - The relationship between the differences in pressure and content of carbon dioxide in arterial and venous blood JO - Clin Sci VL - 32 ID - Mchardy1967 ER - TY - JOUR AU - Jakob, S. M. AU - Kosonen, P. AU - Ruokonen, E. AU - Parviainen, I. AU - Takala, J. PY - 1999 DA - 1999// TI - The Haldane effect—an alternative explanation for increasing gastric mucosal PCO2 gradients? JO - Br J Anaesth VL - 83 UR - https://doi.org/10.1093/bja/83.5.740 DO - 10.1093/bja/83.5.740 ID - Jakob1999 ER - TY - JOUR AU - Ospina-Tascón, G. A. AU - Umaña, M. AU - Bermúdez, W. AU - Bautista-Rincón, D. F. AU - Hernandez, G. AU - Bruhn, A. PY - 2015 DA - 2015// TI - Combination of arterial lactate levels and venous–arterial CO2 to arterial–venous O2 content difference ratio as markers of resuscitation in patients with septic shock JO - Intensive Care Med VL - 41 UR - https://doi.org/10.1007/s00134-015-3720-6 DO - 10.1007/s00134-015-3720-6 ID - Ospina-Tascón2015 ER - TY - JOUR AU - Mesquida, J. AU - Saludes, P. AU - Gruartmoner, G. AU - Espinal, C. AU - Torrents, E. AU - Baigorri, F. PY - 2015 DA - 2015// TI - Central venous-to-arterial carbon dioxide difference combined with arterial-to-venous oxygen content difference is associated with lactate evolution in the hemodynamic resuscitation process in early septic shock JO - Crit Care VL - 19 UR - https://doi.org/10.1186/s13054-015-0858-0 DO - 10.1186/s13054-015-0858-0 ID - Mesquida2015 ER - TY - JOUR AU - Backer, D. PY - 2003 DA - 2003// TI - Lactic acidosis JO - Intensive Care Med VL - 29 ID - Backer2003 ER - TY - JOUR AU - Gore, D. C. AU - Jahoor, F. AU - Hibbert, J. M. AU - DeMaria, E. J. PY - 1996 DA - 1996// TI - Lactic acidosis during sepsis is related to increased pyruvate production, not deficits in tissue oxygen availability JO - Ann Surg VL - 224 UR - https://doi.org/10.1097/00000658-199607000-00015 DO - 10.1097/00000658-199607000-00015 ID - Gore1996 ER - TY - JOUR AU - Vary, T. C. AU - Siegel, J. H. AU - Nakatani, T. AU - Sato, T. AU - Aoyama, H. PY - 1986 DA - 1986// TI - Effect of sepsis on activity of pyruvate dehydrogenase complex in skeletal muscle and liver JO - Am J Physiol VL - 250 ID - Vary1986 ER - TY - JOUR AU - Levraut, J. AU - Ciebiera, J. P. AU - Chave, S. AU - Rabary, O. AU - Jambou, P. AU - Carles, M. PY - 1998 DA - 1998// TI - Mild hyperlactatemia in stable septic patients is due to impaired lactate clearance rather than overproduction JO - Am J Respir Crit Care Med VL - 157 UR - https://doi.org/10.1164/ajrccm.157.4.9705037 DO - 10.1164/ajrccm.157.4.9705037 ID - Levraut1998 ER - TY - JOUR AU - Curtis, S. E. AU - Cain, S. M. PY - 1992 DA - 1992// TI - Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs JO - Am Rev Respir Dis VL - 145 UR - https://doi.org/10.1164/ajrccm/145.2_Pt_1.348 DO - 10.1164/ajrccm/145.2_Pt_1.348 ID - Curtis1992 ER - TY - JOUR AU - Rimachi, R. AU - Bruzzi de Carvahlo, F. AU - Orellano-Jimenez, C. AU - Cotton, F. AU - Vincent, J. L. PY - 2012 DA - 2012// TI - Lactate/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock JO - Anaesth Intensive Care VL - 40 ID - Rimachi2012 ER - TY - JOUR AU - Rivers, E. AU - Nguyen, B. AU - Havstad, S. AU - Ressler, J. AU - Muzzin, A. AU - Knoblich, B. PY - 2001 DA - 2001// TI - Early goal-directed therapy in the treatment of severe sepsis and septic shock JO - N Engl J Med VL - 345 UR - https://doi.org/10.1056/NEJMoa010307 DO - 10.1056/NEJMoa010307 ID - Rivers2001 ER - TY - JOUR AU - Jansen, T. C. AU - Bommel, J. AU - Schoonderbeek, F. J. AU - Sleeswijk Visser, S. J. AU - Klooster, J. M. PY - 2010 DA - 2010// TI - Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial JO - Am J Respir Crit Care Med VL - 182 UR - https://doi.org/10.1164/rccm.200912-1918OC DO - 10.1164/rccm.200912-1918OC ID - Jansen2010 ER - TY - JOUR AU - Chung, K. P. AU - Chang, H. T. AU - Huang, Y. T. AU - Liao, C. H. AU - Ho, C. C. AU - Jerng, J. S. PY - 2012 DA - 2012// TI - Central venous oxygen saturation under non-protocolized resuscitation is not related to survival in severe sepsis or septic shock JO - Shock VL - 38 UR - https://doi.org/10.1097/SHK.0b013e318274c674 DO - 10.1097/SHK.0b013e318274c674 ID - Chung2012 ER - TY - JOUR AU - Boyd, J. H. AU - Forbes, J. AU - Nakada, T. A. AU - Walley, K. R. AU - Russell, J. A. PY - 2011 DA - 2011// TI - Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality JO - Crit Care Med VL - 39 UR - https://doi.org/10.1097/CCM.0b013e3181feeb15 DO - 10.1097/CCM.0b013e3181feeb15 ID - Boyd2011 ER -