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Table 3 Diagnostic ability of baseline values of central venous-to-arterial CO2 tension and content differences to arterial-to-venous oxygen content difference ratios, and baseline lactate values to predict fluid-induced increase in oxygen consumption ≥15 % in fluid-responder patients (n = 51)

From: Ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content are better markers of global anaerobic metabolism than lactate in septic shock patients

  Best cutoff value Se (%) (95 % CI) Sp (%) (95 % CI) PPV (%) (95 % CI) NPV (%) (95 % CI) LR+ (95 % CI) LR (95 % CI)
∆PCO2/∆ContO2 (mmHg/mL) 1.68 90 (71–97) 100 (81–100) 100 (84–100) 88 (68–97) Infinity 0.10 (0.03–0.30)
∆ContCO2/∆ContO2 1.02 86 (67–95) 100 (81–100) 100 (83–100) 85 (64–95) Infinity 0.14 (0.05–0.34)
Lactate (mmol/L) 4.6 69 (49–84) 77 (54–91) 80 (59–92) 65 (44–82) 3.03 (1.35–6.81) 0.40 (0.23–0.71)
  1. Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR + positive likelihood ratio, LR negative likelihood ratio, CI confidence interval