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TableĀ 3 Diagnostic ability of baseline values of central venous-to-arterial CO2 tension and content differences to arterial-to-venous oxygen content difference ratios, and baseline lactate values to predict fluid-induced increase in oxygen consumption ā‰„15Ā % in fluid-responder patients (nĀ =Ā 51)

From: Ratios of central venous-to-arterial carbon dioxide content or tension to arteriovenous oxygen content are better markers of global anaerobic metabolism than lactate in septic shock patients

Ā 

Best cutoff value

Se (%) (95Ā % CI)

Sp (%) (95Ā % CI)

PPV (%) (95Ā % CI)

NPV (%) (95Ā % CI)

LR+ (95Ā % CI)

LRāˆ’ (95Ā % CI)

āˆ†PCO2/āˆ†ContO2 (mmHg/mL)

1.68

90 (71ā€“97)

100 (81ā€“100)

100 (84ā€“100)

88 (68ā€“97)

Infinity

0.10 (0.03ā€“0.30)

āˆ†ContCO2/āˆ†ContO2

1.02

86 (67ā€“95)

100 (81ā€“100)

100 (83ā€“100)

85 (64ā€“95)

Infinity

0.14 (0.05ā€“0.34)

Lactate (mmol/L)

4.6

69 (49ā€“84)

77 (54ā€“91)

80 (59ā€“92)

65 (44ā€“82)

3.03 (1.35ā€“6.81)

0.40 (0.23ā€“0.71)

  1. Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, LR + positive likelihood ratio, LR āˆ’ negative likelihood ratio, CI confidence interval