Respiratory mechanics and lung stress/strain in children with acute respiratory distress syndrome

Annals of Intensive Care

Table 1 Baseline characteristics

Characteristic	ARDS patients (n = 10)	Control patients (n = 10)	p value
Age (years)	2.5 [1.0–5.5]	3.0 [1.7–7.2]	0.62
Male sex, no. of patients (%)	7 (70)	4 (40)	0.37
Height (cm)	99.5 ± 22.2	105.7 ± 14.7	0.47
Weight (kg)	12.7 [10.0–20.2]	15.0 [14.7–18.0]	0.16
Body mass index (kg/m²)	15.1 ± 2.4	15.3 ± 3.0	0.88
V _T (ml)	120.0 [98.7–182.5]	145.0 [127.5–162.5]	0.43
V _T/IBW (ml/kg)	9.1 [7.8–10.0]	9.7 [8.5–10.2]	0.54
Days of ventilation before study	2 [1–4]	0 [0–1]	0.04
ARDS classification, no (%)
Mild	6 (60)
Moderate	2 (20)
Severe	2 (20)
Respiratory rate (bpm)	27 ± 7	22 ± 5	0.09
Minute ventilation (l/min)	3.4 ± 1.1	3.2 ± 0.8	0.64
Airway plateau pressure (cmH₂O)	24.2 ± 4.0	15.1 ± 3.1	<0.001
PEEP (cmH₂O)	8.4 ± 2.3	3.5 ± 1.8	<0.001
PaO₂/FiO₂ ratio	206 ± 86	389 ± 73	<0.001
PaCo₂ (mmHg)	44.0 [37.2–52.5]	40.5 [38.0–45.5]	0.40
FRC (ml)	162.2 ± 67.6	288.1 ± 107.3	0.006
FRC (ml/kg)	10.4 [9.1–14.3]	16.6 [11.7–24.6]	0.04
Admission diagnosis, no (%)			0.004
Sepsis	2 (20)	0
Infection	4 (40)	0
ARDS ndd	3 (30)	0
Post-surgery	0	4 (40)
Neurological diseases	0	4 (40)
Other	1 (10)	2 (20)

Data presented as mean values (SD) or as median [IQ] or as number of subjects (%) as appropriate
V _T tidal volume, IBW ideal body weight, ARDS acute respiratory distress syndrome, PEEP positive end-expiratory pressure, PaO ₂ /FiO ₂ ratio of partial pressure of arterial oxygen and fraction of inspired oxygen, PaCO ₂ partial pressure of arterial carbon dioxide, FRC functional residual capacity