Respiratory mechanics and lung stress/strain in children with acute respiratory distress syndrome

Annals of Intensive Care

Table 3 Lung stress, strain and specific lung elastance

	PEEP (cmH₂O)						p value
	4			12			Pathology	PEEP	V _T
	V_T
	8	10	12	8	10	12
Lung stress (cmH₂O)							<0.001	<0.001	<0.001
ARDS patients	16.0 ± 4.0	17.7 ± 3.8	19.9 ± 3.7	22.9 ± 2.8	24.6 ± 3.0	27.2 ± 2.8
Control patients	9.9 ± 3.1	10.9 ± 3.0	12.2 ± 3.2	15.3 ± 4.4	16.8 ± 4.6	18.4 ± 5.5
Lung strain							0.013	<0.001	0.030
ARDS patients	1.13 ± 0.39	1.32 ± 0.43	1.53 ± 0.46	1.94 ± 0.60	2.19 ± 0.70	2.39 ± 0.86
Control patients	0.94 ± 0.30	1.08 ± 0.36	1.23 ± 0.45	1.80 ± 0.56	1.97 ± 0.67	2.13 ± 0.74
Specific lung elastance (cmH₂O)							<0.001	0.024	0.586
ARDS patients	16.22 ± 7.8	14.21 ± 6.2	13.81 ± 4.8	13.23 ± 4.9	12.41 ± 4.7	12.36 ± 4.9
Control patients	11.24 ± 3.3	10.62 ± 2.3	10.46 ± 2.4	8.98 ± 2.2	9.04 ± 1.8	9.21 ± 1.8

ARDS acute respiratory distress syndrome
Values are mean ± SD. Two statistical analyses are reported: a three-way analysis of variance to test the effects of the presence of the disease, the level of PEEP and the level of VT/IBW and a post hoc Bonferroni’s test analysis for the comparison between subgroups