Table 1 Episodes characteristics at ICU admission and time of C max
From: French Intensive Care Society, International congress – Réanimation 2016
Variables | ECMO (n = 50) | Non-ECMO (n = 50) | P value |
|---|---|---|---|
Characteristics at ICU admission | |||
Age (years) | 61 (43–68) | 63.5 (54–72) | 0.03 |
Cirrhosis | 2 (4) | 4 (8) | 0.68 |
Acute respiratory failure | 7 (14) | 13 (26) | <0.001 |
Severe sepsis/septic shock | 5 (10) | 12 (24) | |
Cardiogenic shock | 21 (42) | 4 (8) | |
Cardiac surgery | 10 (20) | 11 (22) | |
Post-cardiac arrest | 5 (10) | 3 (6) | |
Others | 2 (4) | 7 (14) | |
BMI (kg/m2) | 26.5 (24.2–29.4) | 26.3 (24.5–30.9) | 0.50 |
SAPS II | 51 (42.5–73.3) | 53.5 (41–73.3) | 0.98 |
Characteristics at time of therapeutic monitoring | |||
SOFA score | 12 (10–14) | 9 (6–11) | <0.001 |
24-h fluid balance (mL) | 100 (−925 to 1860) | 100 (−1550 to 1019) | 0.52 |
Weight (kg) | 88.5 (73–100) | 82 (70–93) | 0.37 |
Amikacin dose (mg) | 2250 (1825–2500) | 2000 (1713–2300) | 0.17 |
Amikacin regimen (mg/kg) | 25 (25–25.6) | 24.9 (24.5–25.5) | 0.10 |
Amikacin C max (mg/L) | 71.7 (58.9–79.7) | 68.4 (53–81) | 0.36 |
Patients with C max <60 mg/L | 13 (26) | 17 (34) | 0.51 |
Patients with C max >80mgL | 12 (24) | 15 (30) | 0.65 |
Amikacin C min (mg/L) | 8.5 (3–15.4) | 9.6 (2.5–16.9) | 0.45 |