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Table 1 Baseline characteristics of survivors and non-survivors in hospital in derivation and validation datasets

From: Risk factors for and prediction of mortality in critically ill medical–surgical patients receiving heparin thromboprophylaxis

Characteristics Derivation set (n = 1891) Validation set (n = 1855)
Survivorsa
(n = 1463)
Non-survivorsb
(n = 428)
p value Survivorsc
(n = 1410)
Non-survivorsd
(n = 445)
p value
Age (year): mean (SD) 59.3 (16.92) 67.7 (14.58) <0.001e 59.6 (16.07) 68.3 (14.40) <0.001e
Gender: n (%)
 Male 830 (56.93) 231 (54.10) 0.301f 786 (56.22) 266 (59.91) 0.172f
 Female 628 (43.07) 196 (45.90)   612 (43.78) 178 (40.09)  
BMI (kg/m2): mean (SD) 28.5 (7.69) 27.1 (6.93) <0.001e 28.9 (8.39) 27.1 (6.78) <0.001e
Use of thromboprophylaxis: n (%)
 Unfractionated heparin 718 (49.08) 234 (54.67) 0.042f 696 (49.36) 225 (50.56) 0.659f
 Dalteparin 745 (50.92) 194 (45.33)   714 (50.64) 220 (49.44)  
APACHE II score: mean (SD) 20.8 (7.61) 24.1 (7.59) <0.001e 20.6 (7.59) 24.5 (7.84) <0.001e
History of malignancy: n (%) 50 (3.43) 21 (4.92) 0.155f 47 (3.36) 32 (7.21) <0.001f
Medical admission: n (%) 1086 (74.23) 353 (82.48) <0.001f 1046 (74.18) 346 (77.75) 0.129f
Diagnosis of sepsis on admission: n (%) 208 (14.27) 90 (21.08) <0.001f 177 (12.66) 74 (16.67) 0.032f
Intervention within the first 24 h on admission: n (%)
 Inotropes or vasopressors 614 (42.20) 241 (56.44) <0.001f 579 (41.42) 243 (54.73) <0.001f
 Invasive mechanical ventilation 1207 (82.96) 373 (87.35) 0.030f 1149 (82.19) 380 (85.59) 0.097f
 Dialysis 57 (3.92) 45 (10.54) <0.001f 87 (6.22) 39 (8.78) 0.063f
 Acetylsalicylic acid or clopidogrel 290 (19.93) 113 (26.46) 0.004f 289 (20.49) 112 (25.23) 0.029f
 Statin 169 (11.62) 62 (14.52) 0.108f 199 (14.23) 59 (13.29) 0.617f
  1. aMedian follow-up: 18 days; interquartile range (IQR): 11–33 days
  2. bMedian survival time: 14 days; IQR 7.5–28 days
  3. cMedian follow-up: 19 days; IQR 11–37 days
  4. dMedian survival time: 15 days; IQR 7–29 days
  5. eStudent’s t test
  6. fChi-square test