References | Subjects of RCT | Industry sponsored? | Geographical setting | Intervention group | Control group |
---|---|---|---|---|---|
Hayes [10] | Critically ill | No | UK | High DO2 | Normal DO2 |
Fisher [15] | Septic shock | Yes | USA | TNF-α receptor | Placebo |
Sloan [14] | Hemorrhagic shock | Yes | USA | Diaspirin-hemoglobin | Normal saline |
Takala [13] | Critically ill | Yes | EU | Growth hormone | Placebo |
Edwards [17] | Head injury | No | UK | Methylprednisolone | Placebo |
Perner [12] | Severe sepsis | No | Scandinavia | Hetastarch (HES130/0.42) | Ringers lactate |
Ferguson [16] | ARDS | No | Canada | High-frequency oscillation | Control ventilation strategy targeting lung recruitment |
Finfer [8] | Critically ill | No | Australia/New Zealand/Canada | Intensive insulin | Normal insulin |
Lopez [11] | Septic shock | Yes | EU/North America | iNOS inhibitor (546C88) | Placebo |
Gao Smith [9] | ALI/ARDS | No | USA | IV salbutamol | Placebo |