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Table 1 Subjects, industry sponsorship, geographical settings and interventions tested in adult critical care RCTs with increased mortality in intervention groups

From: Trials in adult critical care that show increased mortality of the new intervention: Inevitable or preventable mishaps?

References

Subjects of RCT

Industry sponsored?

Geographical setting

Intervention group

Control group

Hayes [10]

Critically ill

No

UK

High DO2

Normal DO2

Fisher [15]

Septic shock

Yes

USA

TNF-α receptor

Placebo

Sloan [14]

Hemorrhagic shock

Yes

USA

Diaspirin-hemoglobin

Normal saline

Takala [13]

Critically ill

Yes

EU

Growth hormone

Placebo

Edwards [17]

Head injury

No

UK

Methylprednisolone

Placebo

Perner [12]

Severe sepsis

No

Scandinavia

Hetastarch (HES130/0.42)

Ringers lactate

Ferguson [16]

ARDS

No

Canada

High-frequency oscillation

Control ventilation strategy targeting lung recruitment

Finfer [8]

Critically ill

No

Australia/New Zealand/Canada

Intensive insulin

Normal insulin

Lopez [11]

Septic shock

Yes

EU/North America

iNOS inhibitor (546C88)

Placebo

Gao Smith [9]

ALI/ARDS

No

USA

IV salbutamol

Placebo

  1. DO2 oxygen delivery, NS normal saline, iNOS inducible nitric oxide synthase, IV intravenous, ARDS acute respiratory distress syndrome