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Table 3 Randomized controlled trials in adult ECMO

From: Concepts from paediatric extracorporeal membrane oxygenation for adult intensivists

Author (ref no) CMV (lived/total) ECMO (lived/total) Pro-ECMO Anti-ECMO Today’s perspective
Zapol et al. [1] 4/48 (8 %) 4/42 (10 %) Change needed? Different patients with different diseases Does not work VV not used, ECMO duration arbitrarily limited to 5 days, ECMO started very late
Morris et al. [7] 8/19 (42 %) 7/21 (33 %) 2/3 death due to bleeding, learning curve Does not work, protocols are better Small study, outdated ECMO technology, training is important
Peek et al. [8] 41/87 (47 %) 57/90 (63 %) ECMO works Only 68 % received ECMO Intention to treat analysis,
ECMO in care plan probably beneficial but still unproven
  1. CMV conventional mechanical ventilation, ECMO extracorporeal membrane oxygenation, VV venovenous, CESAR conventional ventilator support versus extracorporeal membrane oxygenation for severe adult respiratory failure