Table 4 Randomized controlled trials in neonatal and paediatric ECMO
From: Concepts from paediatric extracorporeal membrane oxygenation for adult intensivists
Author (ref no) | CMV (lived/total) | ECMO (lived/total) | Pro-ECMO | Anti-ECMO | Today |
|---|---|---|---|---|---|
Bartlett et al. [52] | 0/1 (0 %) | 11/11 (100 %) | It works, novel study design to minimize death rate | Amazement that the study was approved by the review board | Play the winner, possible bias, small numbers |
O’Rourke et al. [53] | 6/10 (60 %) | 28/29 (97 %) | It works | It might work but is unproven | Small numbers |
UK neonatal study [9] | 38/92 (41 %) | 63/93 (68 %) | It works | No standardized protocol for treatment of control patients | Suggestive of benefit but some methodological problems |