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Table 1 ICU admission main characteristics, supportive therapies, outcome for all patients and ICU survivors or dead

From: Outcome of a cohort of severe cerebral venous thrombosis in intensive care

  Total CVT
n = 41
ICU deaths
n = 10
ICU survivors
n = 31
p value
Age (years) 47 (26–53) 44.5 (30.8–52) 47 (24–51.5) 0.82
Sex female (%) 30 (73.2) 10 (100) 20 (75.6) 0.039
SAPS II 41 (32–45) 42.5 (41–52.5) 35 (31.5–44.5) 0.072
Delay for diagnosis (days) 3 (1–7) 3 (1–5.5) 3 (1–7) 0.73
Delay diagnosis–ICU admission (days) 1 (0–3) 0 (0–1) 1 (1–4.5) 0.029
GCS (lowest) 7 (5–8) 4 (3–6) 8 (6–9) 0.0004
Seizure in ICU [n (%)] 18 (43.9) 4 (40) 14 (45.2) 1.00
Mydriasis [n (%)] 20 (48.8) 10 (100) 10 (32.3) 0.0001
Hematoma [n (%)] 32 (78.0) 10 (100) 22 (70.9) 0.083
Heparin before admission [n (%)] 25 (60.9) 5 (50) 20 (75.6) 0.47
aPTT ratio > 2 within 48 h [n (%)] 30 (80.5) 5 (50) 25 (80.6) 0.098
Craniectomy (n (%)) 16 (39.0) 5 (50) 11 (35.5) 0.47
Endovascular treatment [n (%)] 9 (21.9) 3 (30) 6 (19.4) 0.66
CSF shunt [n (%)] 7 (17.7) 2 (20) 5 (16.1) 1.00
IV norepinephrine [n (%)] 26 (63.4) 9 (90) 17 (54.8) 0.063
MAP min day 1 (mmHg) 76 (66–86) 83 (70–98) 76 (65–83) 0.23
MAP min day 2 (mmHg) 75 (71–84) 73 (59–91) 76 (72–83) 0.56
Mechanical ventilation [n (%)] 37 (90.2) 10 (100) 27 (87.1) 0.55
Fluid balance day 1 (mL) −188 (−482 to +393) −350 (−1224 to −145) −188 (−440 to +429) 0.45
Fluid balance day 2 (mL) 247 (−756 to +809) −50 (−679 to +878) 344 (−782 to +797) 0.59
Natremia day 1 (mM) 138 (135–142) 139 (137–141) 137 (135–142) 0.64
Platelet count day 1 (109/L) 231 (181–305) 210 (162–239) 240 (205–309) 0.23
Glycemia day 1 (mM) 7.1 (6.1–8.3) 7.5 (6.2–10.8) 7.1 (5.9–7.8) 0.19
mRS at discharge 4 (3–5) 6 3 (2.5–4)
mRS at 3 months (n = 23) 3 (2–4) 3 (2–4)
mRS at 12 months (n = 18) 2 (1–3) 2 (1–3)
mRS at last follow-up 2 (1–6) 6 2 (0.5–3)
  1. Median and interquartile or proportion p < 0.05 were considered as statistically significant. CVT cerebral vein thrombosis, ICU intensive care unit, SAPS II: Simplified Acute Physiology Score II, GCS Glasgow Coma Scale, aPPT activated partial thromboplastin time, CSF cerebral spinal fluid. IV intravenous, MAP mean arterial pressure, Min minimal, mRS modified Rankin score