From: Predictors of haemodynamic instability during the changeover of norepinephrine infusion pumps
Total (n = 764) | No incidenta (n = 650) | ≥1 incidenta (n = 114) | p | |
---|---|---|---|---|
Haemodynamics | ||||
MAP (mmHg)c | 67 (59–76) | 67 (59–76) | 67 (59–74) | 0.70 |
Heart rate (bpm)c | 107 (93–123) | 107 (94–123) | 105 (87–119) | 0.06 |
Organ supportsb | ||||
Mechanical ventilation | 729 (95) | 616 (95) | 113 (99) | 0.04 |
Renal replacement therapy | 470 (62) | 397 (61) | 73 (64) | 0.60 |
Norepinephrine infusionc | ||||
Flow rates (ml h−1) | 5.4 (3.3–7.8) | 5.7 (3.5–8.0) | 4.0 (2.8–6.6) | 0.001 |
Doses (μg kg−1 min−1) | 0.6 (0.2–1.1) | 0.6 (0.2–1.2) | 0.4 (0.2–1.0) | <0.01 |
Norepinephrine concentration | ||||
Concentration (mg ml−1)c | 0.5 (0.2–0.5) | 0.5 (0.25–0.5) | 0.5 (0.5–0.5) | 0.68 |
No change in concentrationb | 650 (85.1) | 594 (91.4) | 56 (49.1) | <0.0001 |
Change in concentrationb | 114 (14.9) | 56 (8.6) | 58 (50.9) | <0.0001 |
Decrease | 68 (8.9) | 25 (3.8) | 43 (37.7) | <0.0001 |
Increase | 46 (6.0) | 31 (4.8) | 15 (13.2) | <0.001 |
CNIP orderb | 0.95 | |||
First | 118 (15) | 101 (16) | 17 (15) | – |
2–5th | 297 (39) | 251 (39) | 46 (40) | – |
>5th | 349 (46) | 298 (46) | 51 (45) | – |