Skip to main content

Table 2 Characteristics of the changeovers of norepinephrine syringe pumps

From: Predictors of haemodynamic instability during the changeover of norepinephrine infusion pumps

 

Total

(n = 764)

No incidenta

(n = 650)

≥1 incidenta

(n = 114)

p

Haemodynamics

 MAP (mmHg)c

67 (59–76)

67 (59–76)

67 (59–74)

0.70

 Heart rate (bpm)c

107 (93–123)

107 (94–123)

105 (87–119)

0.06

Organ supportsb

 Mechanical ventilation

729 (95)

616 (95)

113 (99)

0.04

 Renal replacement therapy

470 (62)

397 (61)

73 (64)

0.60

Norepinephrine infusionc

 Flow rates (ml h−1)

5.4 (3.3–7.8)

5.7 (3.5–8.0)

4.0 (2.8–6.6)

0.001

 Doses (μg kg−1 min−1)

0.6 (0.2–1.1)

0.6 (0.2–1.2)

0.4 (0.2–1.0)

<0.01

Norepinephrine concentration

 Concentration (mg ml−1)c

0.5 (0.2–0.5)

0.5 (0.25–0.5)

0.5 (0.5–0.5)

0.68

 No change in concentrationb

650 (85.1)

594 (91.4)

56 (49.1)

<0.0001

 Change in concentrationb

114 (14.9)

56 (8.6)

58 (50.9)

<0.0001

  Decrease

68 (8.9)

25 (3.8)

43 (37.7)

<0.0001

  Increase

46 (6.0)

31 (4.8)

15 (13.2)

<0.001

CNIP orderb

0.95

 First

118 (15)

101 (16)

17 (15)

 2–5th

297 (39)

251 (39)

46 (40)

 >5th

349 (46)

298 (46)

51 (45)

  1. aIncident during changeover of norepinephrine syringe pumps (CNIP) was defined as a change in mean arterial pressure (MAP) >25 %
  2. bData are expressed as number (%) of patients
  3. cData are expressed as median values and IQRs