Annals of Intensive Care

Table 5 Interaction between the norepinephrine dose and the risk of CNIP-induced haemodynamic instability based on changes in the norepinephrine concentration

From: Predictors of haemodynamic instability during the changeover of norepinephrine infusion pumps

	Overall (n = 764)		Dose < 0.5 μg kg⁻¹ min⁻¹ (n = 324)		Dose ≥ 0.5 μg kg⁻¹ min⁻¹ (n = 440)
	Adjusted OR^a (95 % CI)	p	Adjusted OR^a (95 % CI)	p	Adjusted OR^a (95 % CI)	p
No change in concentration	1.00 (Ref.)	–	1.00 (Ref.)	–	1.00 (Ref.)	–
Decrease in concentration	20.7 (11.0–39.0)	<0.001	28.9 (13.5–61.8)	<0.001	7.8 (1.5–41.3)	<0.01
Increase in concentration	5.4 (2.7–10.9)	<0.001	33.2 (6.0–182.3)	<0.001	3.4 (1.4–8.1)	<0.01

CNIP Changeover of norepinephrine syringe pumps, OR odds ratio, CI confidence intervals
^aAfter multivariate mixed effects logistic regression

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