TY - JOUR AU - Ichai, Carole AU - Vinsonneau, Christophe AU - Souweine, Bertrand AU - Armando, Fabien AU - Canet, Emmanuel AU - Clec’h, Christophe AU - Constantin, Jean-Michel AU - Darmon, Michaël AU - Duranteau, Jacques AU - Gaillot, Théophille AU - Garnier, Arnaud AU - Jacob, Laurent AU - Joannes-Boyau, Olivier AU - Juillard, Laurent AU - Journois, Didier AU - Lautrette, Alexandre AU - Muller, Laurent AU - Legrand, Matthieu AU - Lerolle, Nicolas AU - Rimmelé, Thomas AU - Rondeau, Eric AU - Tamion, Fabienne AU - Walrave, Yannick AU - Velly, Lionel AU - Société française d’anesthésie et de réanimation (Sfar) AU - Société de réanimation de langue française (SRLF) AU - Groupe francophone de réanimation et urgences pédiatriques (GFRUP) AU - Société française de néphrologie (SFN) PY - 2016 DA - 2016/05/27 TI - Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies) JO - Annals of Intensive Care SP - 48 VL - 6 IS - 1 AB - Acute kidney injury (AKI) is a syndrome that has progressed a great deal over the last 20 years. The decrease in urine output and the increase in classical renal biomarkers, such as blood urea nitrogen and serum creatinine, have largely been used as surrogate markers for decreased glomerular filtration rate (GFR), which defines AKI. However, using such markers of GFR as criteria for diagnosing AKI has several limits including the difficult diagnosis of non-organic AKI, also called “functional renal insufficiency” or “pre-renal insufficiency”. This situation is characterized by an oliguria and an increase in creatininemia as a consequence of a reduction in renal blood flow related to systemic haemodynamic abnormalities. In this situation, “renal insufficiency” seems rather inappropriate as kidney function is not impaired. On the contrary, the kidney delivers an appropriate response aiming to recover optimal systemic physiological haemodynamic conditions. Considering the kidney as insufficient is erroneous because this suggests that it does not work correctly, whereas the opposite is occurring, because the kidney is healthy even in a threatening situation. With current definitions of AKI, normalization of volaemia is needed before defining AKI in order to avoid this pitfall. SN - 2110-5820 UR - https://doi.org/10.1186/s13613-016-0145-5 DO - 10.1186/s13613-016-0145-5 ID - Ichai2016 ER -