Skip to main content

Table 3 Changes in haemodynamic variables

From: The passive leg raising test to guide fluid removal in critically ill patients

  Baseline PLR
(% change from baseline)
H1 H2 H3 H4 H5 H6
Number of patients at this time of the study
 Patients without intradialytic hypotension 26 26   26 26 25 23 8 7
 Patients with intradialytic hypotension 13 13   13 9 5 2 0 0
Heart rate (beats/min)
 Patients without intradialytic hypotension 93 [81–106] 91 [79–101] 0 [-2–1] 90 [78–104] 93 [78–103] 91 [81–109] 89 [78–107] 97 [84–110] 97 [94–119.00]
 Patients with intradialytic hypotension 95 [90–98] 95 [91–97] 0 [1–1] 91 [90–99] 93 [73–102] 89 [68–96] 103 [96–111]
Systolic arterial pressure (mmHg)*
 Patients without intradialytic hypotension 130 [120–151] 134 [120–151] 0 [0–3] 125 [115–153] 131 [118–148] 128 [113–150] 130 [110–149] 117 [109–140] 97 [94–119.00]
 Patients with intradialytic hypotension 117 [102–131] 120 [111–130] 0 [0–3] 112 [108–120] 105 [102–108] 108 [98–109] 105 [92–119]
Mean arterial pressure (mmHg)
 Patients without intradialytic hypotension 87 [82–98] 90 [82–102] 0 [-1–3] 84 [78–95] 90 [80–96] 90 [76–96] 86 [79–94] 82 [74–92] 67 [66–61.00]
 Patients with intradialytic hypotension 87 [79–89] 88 [82–92] 2 [-1–5] 81 [69–84] 75 [69–83] 68 [68–85] 78 [72–84]
Diastolic arterial pressure (mmHg)*
 Patients without intradialytic hypotension 64 [57–73] 64 [58–75] 0 [0–4] 62 [56–69] 65 [57–71] 65 [52–72] 61 [58–67] 63 [56–68] 57 [53–60.00]
 Patients with intradialytic hypotension 65 [63–71] 68 [60–71] 1 [0–4] 63 [46–70] 59 [54–63] 51 [48–61] 62 [21–63]
Cardiac index (L/min/m2)*
 Patients without intradialytic hypotension 3.5 [2.7–4.2] 3.6 [2.9–4.1] 2 [0–5] 3.4 [2.6–3.8] 3.1 [2.6–3.8] 3.4 [2.2–3.8] 3.1 [2.6–3.7] 2.8 [2.5–3.4] 2.6 [2.4–2.9]
 Patients with intradialytic hypotension 3.0 [2.3–3.2] 3.5 [3.1–4.0] 15 [11–36] 2.4 [1.7–2.8] 2.3 [1.6–2.3] 1.5 [1.4–2.1] 1.9 [1.5–2.2]
Global end-diastolic volume (mL/m2)
 Patients without intradialytic hypotension 765 [654–834]    716 [609–786] 685 [597–786] 707 [588–846] 712 [626–772] 812 [652–921] 865 [632–935]
 Patients with intradialytic hypotension 700 [626–749]    693 [570–709] 641 [584–710] 500 [500–663] 539 [503–574]
Extravascular lung water (mL/kg)
 Patients without intradialytic hypotension 11 [8–16]    11 [8–15] 9 [8–15] 8 [8–14] 8 [7–12] 7 [6–9] 9 [6–11]
 Patients with intradialytic hypotension 8 [7–14]    8 [7–15] 8 [7–13] 6 [5–7] 5 [5–6]
Cardiac function index (min−1)
 Patients without intradialytic hypotension 4.5 [3.5–5.4]    4.4 [4.1–5.2] 4.7 [3.9–5.6] 4.1 [3.8–5.1] 4.8 [4.0–5.0] 4.0 [3.8–4.1] 3.5 [3.0–4.4]
 Patients with intradialytic hypotension 4 [3.5–5.0]    4.1 [2.9–5.0] 3.4 [2.5–4.1] 4.3 [3.4–5.2] 4.3 [4.0–4.5]
Volume of fluid removed (mL)
 Patients without intradialytic hypotension   1000 [660–1000] 2000 [1320–2000] 3000 [1860–3000] 4000 [2480–4000] 3300 [2900–5000] 4980 [3240–6000]
 Patients with intradialytic hypotension   660 [500–1000] 2000 [1320–2000] 1980 [1500–3000] 3000 [2500–3500]
Body temperature
 Patients without intradialytic hypotension 37.6 [37.0–38.3]   37.6 [37.0–38.3] 37.6 [36.9–38.3] 37.3 [36.6–38.0] 37.2 [36.4–38.0] 37.2 [36.8–37.8] 37.2 [36.8–37.8]
 Patients with intradialytic hypotension 37.5 [36.9–37.9]   37.5 [36.9–37.9] 37.4 [36.7–37.9] 37.6 [36.6–38.2] 37.0 [36.8–37.3]
  1. Values were recorded before (baseline) and during PLR. Afterwards, they were recorded 1, 2, 3, 4, 5 and 6 h after starting renal replacement therapy (H1–H6)
  2. Values are expressed as median [interquartile range] or number and frequency in  %
  3. PLR passive leg raising
  4. p < 0 .05 for these variables, the slope from H1 to the end of renal replacement therapy or intolerance was significantly different from 1 and was higher in patients with no versus patients with intradialytic hypotension