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Table 3 Changes in haemodynamic variables

From: The passive leg raising test to guide fluid removal in critically ill patients

 

Baseline

PLR

(% change from baseline)

H1

H2

H3

H4

H5

H6

Number of patients at this time of the study

 Patients without intradialytic hypotension

26

26

 

26

26

25

23

8

7

 Patients with intradialytic hypotension

13

13

 

13

9

5

2

0

0

Heart rate (beats/min)

 Patients without intradialytic hypotension

93 [81–106]

91 [79–101]

0 [-2–1]

90 [78–104]

93 [78–103]

91 [81–109]

89 [78–107]

97 [84–110]

97 [94–119.00]

 Patients with intradialytic hypotension

95 [90–98]

95 [91–97]

0 [1–1]

91 [90–99]

93 [73–102]

89 [68–96]

103 [96–111]

Systolic arterial pressure (mmHg)*

 Patients without intradialytic hypotension

130 [120–151]

134 [120–151]

0 [0–3]

125 [115–153]

131 [118–148]

128 [113–150]

130 [110–149]

117 [109–140]

97 [94–119.00]

 Patients with intradialytic hypotension

117 [102–131]

120 [111–130]

0 [0–3]

112 [108–120]

105 [102–108]

108 [98–109]

105 [92–119]

Mean arterial pressure (mmHg)

 Patients without intradialytic hypotension

87 [82–98]

90 [82–102]

0 [-1–3]

84 [78–95]

90 [80–96]

90 [76–96]

86 [79–94]

82 [74–92]

67 [66–61.00]

 Patients with intradialytic hypotension

87 [79–89]

88 [82–92]

2 [-1–5]

81 [69–84]

75 [69–83]

68 [68–85]

78 [72–84]

Diastolic arterial pressure (mmHg)*

 Patients without intradialytic hypotension

64 [57–73]

64 [58–75]

0 [0–4]

62 [56–69]

65 [57–71]

65 [52–72]

61 [58–67]

63 [56–68]

57 [53–60.00]

 Patients with intradialytic hypotension

65 [63–71]

68 [60–71]

1 [0–4]

63 [46–70]

59 [54–63]

51 [48–61]

62 [21–63]

Cardiac index (L/min/m2)*

 Patients without intradialytic hypotension

3.5 [2.7–4.2]

3.6 [2.9–4.1]

2 [0–5]

3.4 [2.6–3.8]

3.1 [2.6–3.8]

3.4 [2.2–3.8]

3.1 [2.6–3.7]

2.8 [2.5–3.4]

2.6 [2.4–2.9]

 Patients with intradialytic hypotension

3.0 [2.3–3.2]

3.5 [3.1–4.0]

15 [11–36]

2.4 [1.7–2.8]

2.3 [1.6–2.3]

1.5 [1.4–2.1]

1.9 [1.5–2.2]

Global end-diastolic volume (mL/m2)

 Patients without intradialytic hypotension

765 [654–834]

  

716 [609–786]

685 [597–786]

707 [588–846]

712 [626–772]

812 [652–921]

865 [632–935]

 Patients with intradialytic hypotension

700 [626–749]

  

693 [570–709]

641 [584–710]

500 [500–663]

539 [503–574]

Extravascular lung water (mL/kg)

 Patients without intradialytic hypotension

11 [8–16]

  

11 [8–15]

9 [8–15]

8 [8–14]

8 [7–12]

7 [6–9]

9 [6–11]

 Patients with intradialytic hypotension

8 [7–14]

  

8 [7–15]

8 [7–13]

6 [5–7]

5 [5–6]

Cardiac function index (min−1)

 Patients without intradialytic hypotension

4.5 [3.5–5.4]

  

4.4 [4.1–5.2]

4.7 [3.9–5.6]

4.1 [3.8–5.1]

4.8 [4.0–5.0]

4.0 [3.8–4.1]

3.5 [3.0–4.4]

 Patients with intradialytic hypotension

4 [3.5–5.0]

  

4.1 [2.9–5.0]

3.4 [2.5–4.1]

4.3 [3.4–5.2]

4.3 [4.0–4.5]

Volume of fluid removed (mL)

 Patients without intradialytic hypotension

 

1000 [660–1000]

2000 [1320–2000]

3000 [1860–3000]

4000 [2480–4000]

3300 [2900–5000]

4980 [3240–6000]

 Patients with intradialytic hypotension

 

660 [500–1000]

2000 [1320–2000]

1980 [1500–3000]

3000 [2500–3500]

Body temperature

 Patients without intradialytic hypotension

37.6 [37.0–38.3]

 

37.6 [37.0–38.3]

37.6 [36.9–38.3]

37.3 [36.6–38.0]

37.2 [36.4–38.0]

37.2 [36.8–37.8]

37.2 [36.8–37.8]

 Patients with intradialytic hypotension

37.5 [36.9–37.9]

 

37.5 [36.9–37.9]

37.4 [36.7–37.9]

37.6 [36.6–38.2]

37.0 [36.8–37.3]

  1. Values were recorded before (baseline) and during PLR. Afterwards, they were recorded 1, 2, 3, 4, 5 and 6 h after starting renal replacement therapy (H1–H6)
  2. Values are expressed as median [interquartile range] or number and frequency in  %
  3. PLR passive leg raising
  4. p < 0 .05 for these variables, the slope from H1 to the end of renal replacement therapy or intolerance was significantly different from 1 and was higher in patients with no versus patients with intradialytic hypotension