Skip to main content

Table 3 Multivariate analysis of variables associated with outcomes in the overall population

From: High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study

  Adjusted odds ratio (95 % CI) p value
Variables independently associated with intubation a   
Simplified Acute Physiology Score II, per point 1.04 (1.00–1.08) 0.04
Noninvasive ventilation as a first-line therapy 3.25 (1.39–7.60) 0.007
Use of vasopressors within 24 h after ICU admission 4.12 (1.32–12.84) 0.02
Variables independently associated with mortality at day 28 b   
Age (per year) 1.03 (1.00–1.07) 0.04
Use of vasopressors within 24 h after ICU admission 2.83 (1.02–7.91) 0.047
Noninvasive ventilation as a first-line therapy 3.70 (1.49–9.19) 0.005
  1. aNon-collinear variables included in the logistical regression model were Simplified Acute Physiology Score II, Noninvasive ventilation as a first-line therapy, use of vasopressors within 24 h after ICU admission, SpO2 at ICU admission, cause of respiratory failure and PaCO2 as a continuous variable. The year of ICU admission was forced in the model
  2. bNon-collinear variables included in the logistical regression model were age, PaO2-to-FiO2 ratio at ICU admission, use of noninvasive ventilation as a first-line therapy, type of immunosuppression, use of vasopressors in the 24 h after ICU admission, cause of respiratory failure and PaCO2 > 45 mmHg. The year of ICU admission was forced in the model