Combination of C-reactive protein, procalcitonin and sepsis-related organ failure score for the diagnosis of sepsis in critical patients

Annals of Intensive Care

Table 2 Diagnostic value of each parameter in sepsis

Variables	AUC	P value	Sensitivity	Specificity	+LR	−LR
All patients
SOFA	0.671	<0.001	66.4	61.7	1.73	0.55
CRP	0.729	<0.001	90.7	49.7	1.80	0.19
PCT	0.737	<0.001	82.9	53.9	1.80	0.32
IL-6	0.511	0.760	28.2	78.7	1.32	0.91
Score	0.790	<0.001	78.5	70.0	2.61	0.31
Surgical patients
SOFA	0.587	0.150	51.7	62.6	1.38	0.77
CRP	0.697	<0.001	89.7	45.0	1.63	0.23
PCT	0.698	<0.001	65.5	71.0	2.26	0.49
IL-6	0.522	0.713	75.9	36.4	1.19	0.66
Score	0.745	<0.001	82.8	63.4	2.26	0.27
Non-surgical patients
SOFA	0.684	<0.001	71.8	59.7	1.78	0.47
CRP	0.762	<0.001	91.0	59.7	2.26	0.15
PCT	0.810	<0.001	75.0	77.4	3.32	0.32
IL-6	0.503	0.953	68.1	43.3	1.20	0.74
Score	0.836	<0.001	78.2	77.4	3.46	0.28
Newly hospitalized patients
SOFA	0.781	<0.001	84.6	66.0	2.49	0.23
CRP	0.805	<0.001	89.7	66.0	2.64	0.16
PCT	0.868	<0.001	84.6	80.9	4.42	0.19
IL-6	0.601	0.101	82.1	44.7	1.48	0.40
Score	0.896	<0.001	84.6	83.0	4.97	0.19