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Table 6 Univariable and multivariable logistic regression analyses of factors associated with ICU mortality in ARDS patients

From: Aspergillus-positive lower respiratory tract samples in patients with the acute respiratory distress syndrome: a 10-year retrospective study

 

n

Death

n (%)

Univariable analysis

Multivariable analysis

OR (95 % CI)

p

aOR (95 % CI)

p

Age (years)

1.02 (1.01–1.03)

<0.0001

1.02 (1.00–1.03)

0.029

Year of inclusion

0.89 (0.82–0.95)

<0.001

Liver cirrhosis

 Yes

44

31 (70.5)

2.69 (1.37–5.31)

0.004

2.62 (1.24–5.54)

0.012

 No

379

178 (47.0)

1

 

1

 

Immunosuppression

 Yes

100

58 (58.0)

1.57 (1.00–2.47)

0.050

1.83 (1.08–3.11)

0.024

 No

323

151 (46.7)

1

 

1

 

PaO2/FiO2 ratio (mmHg)

0.99 (0.99–0.99)

<0.0001

0.99 (0.99–0.99)

<0.0001

SAPS II

1.03 (1.02–1.04)

<0.0001

1.02 (1.00–1.03)

0.018

LODS

1.19 (1.13–1.25)

<0.0001

1.12 (1.05–1.20)

<0.001

Antifungal treatmenta

 Yes

17

12 (70.6)

2.55 (0.88–7.36)

0.084

 No

406

197 (48.5)

1

   

Blot et al. algorithm[16]

 No Aspergillus spp. colonization

388

188 (48.5)

1

1

 Aspergillus spp. colonization

18

6 (33.3)

0.53 (0.20–1.45)

0.22

0.64 (0.21–1.99)

0.44

 Putative or proven IPA

17

15 (88.2)

7.98 (1.80–35.36)

0.006

9.58 (1.97–46.52)

0.005

  1. IPA invasive pulmonary aspergillosis
  2. aAs prescribed for a suspicion of invasive pulmonary aspergillosis; the Hosmer–Lemeshow goodness of fit test showed good calibration of the model (p = 0.28); the area under the curve of the model is 0.78 (0.73–0.82); OR (95 % CI), odds ratio (95 % confidence interval); aOR, adjusted odds ratio