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Table 4 Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PCT and Presepsin and their combinations for severe sepsis and septic shock and for pneumonia diagnoses

From: Diagnostic and prognostic value of soluble CD14 subtype (Presepsin) for sepsis and community-acquired pneumonia in ICU patients

  Sensitivity (%) Specificity (%) PPV (%) NPV (%)
SS and SSh
 PCTa 80 59 82 57
 Presepsinb 90 55 82 71
 PCT and Presepsin 75 68 85 55
Pneumonia
 PCTa 69 80 93 40
 Presepsinc 81 80 94 52
 PCT and Presepsin 62 93 97 62
  1. SS severe sepsis, SSh septic shock, PPV positive predictive value, NPV negative predictive value
  2. aCutoff value for PCT at 0.5 ng/mL
  3. bCutoff value for Presepsin at 466 pg/mL
  4. cCutoff value for Presepsin at 588 pg/mL