Immature/total granulocyte ratio improves early prediction of neurological outcome after out-of-hospital cardiac arrest: the MyeloScore study

Annals of Intensive Care

Table 2 Univariate analysis of factors associated with outcome at hospital discharge after out-of-hospital cardiac arrest

Variable	CPC 3–5 (n = 140)	CPC 1–2 (n = 64)	P
Patient demographics
Age (years)	61 [48–69]	53 [46–62]	0.02
Male sex, n (%)	102 (73)	54 (84.5)	0.14
Body mass index (kg/m²)	25.5 [22–29.5]	26.4 [23.1–28]	0.71
Charlson comorbidity index	1 [0–1]	0 [0–1]	0.31
OHCA characteristics
Location of OHCA, n (%)			0.005
Public place	36 (26)	29 (45.5)
Private place	104 (74)	35 (54.5)
Witnessed OHCA, n (%)	109 (78)	59 (92)	0.02
Bystander CPR, n (%)	60 (43)	50 (78)	<0.001
Arrest rhythm, n (%)			<0.001
Initial VF/VT	47 (33.5)	44 (69)
PEA/asystole	93 (66.5)	20 (31)
No-flow time (min)	6 [1–10.5]	0 [0–1]	<0.001
Low-flow time (min)	23 [15–30.5]	16 [10–25]	0.003
On-scene epinephrine dose (mg)	3 [1.5–5]	1 [0–3]	<0.001
Laboratory values at ICU admission
Arterial lactate (mmol/L)	5 [2.5–8.4]	2 [1.5–4.3]	<0.001
Creatinine (µmol/L)	113 [90–149]	92 [75–111]	<0.001
Troponin (µg/L)	0.8 [0.1–8]	1.7 [0.3–16]	0.07
Leukocytes (g/L)	14.5 [11–19.5]	15 [11.5–20]	0.53
Neutrophils (g/L)	11.5 [8–15]	13 [9–17]	0.15
I/T-G ratio (%)	1.5 [0.5–2.5]	0.5 [0.3–0.9]	<0.001
Severity scores
SOFA on day 1	11 [8.5–14]	9.5 [7–11]	0.001
SAPS II on day 1	74 [61–85]	63.5 [50–72]	<0.001
OHCA score	38.5 [22–46]	5 [–3–18	<0.001
CAHP score	184.5 [156–210]	144 [113–165]	<0.001
Hospital data
Admission temperature (°C)	35 [34–35.5]	35 [34.5–36]	0.20
Therapeutic hypothermia, n (%)	75 (53.5)	55 (86)	<0.001
Early coronary angioplasty, n (%)	29 (20.5)	33 (51.5)	0.003
Postresuscitation shock, n (%)	79 (56.5)	28 (44)	0.09
Hospital length of stay (days)	5 [3–9]	16 [12–21]	<0.001

Data are expressed in median [IQR] and n (%)
No-flow time is the time between collapse and base life support. Low-flow time is the time between base life support and return of spontaneous circulation
CPC cerebral performance category, OHCA out-of-hospital cardiac arrest, CPR cardiopulmonary resuscitation, VF/VT ventricular fibrillation/ventricular tachycardia, PEA pulseless electrical activity, I/T-G ratio of immature over total granulocytes in peripheral blood, SOFA Sequential Organ Failure Assessment, SAPS II Simplified Acute Physiology Score version II