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Table 2 Respiratory system mechanics, gas exchange and hemodynamic data during the study

From: End-inspiratory pause prolongation in acute respiratory distress syndrome patients: effects on gas exchange and mechanics

  Phase 1 (baseline) Phase 2 (EIP prolongation) Phase 3 (Vt reduction) Overall p value Intergroup differences
EIP (s) 0.12 ± 0.04 0.7 ± 0 0.7 ± 0 <0.001 a, b
Ppeak (cmH2O) 38 ± 6 38 ± 6 35 ± 5 <0.001 b, c
Pmean (cmH2O) 15 ± 3 18 ± 2 17 ± 2 <0.001 a, b, c
Pplat (cmH2O) 24 ± 3 24 ± 3 22 ± 3 <0.001 b, c
PEEPi (cmH2O) 0.2 ± 0.2 0.5 ± 0.4 0.5 ± 0.4 0.06  
Vt (mL) 378 ± 73 378 ± 73 336 ± 61 <0.001 b, c
Vt (PBW; mL/Kg) 6.3 ± 0.8 6.3 ± 0.8 5.6 ± 0.8 <0.001 b, c
Vdphys (mL) 267 ± 71 244 ± 65 216 ± 58 <0.001 a, b, c
Vd/Vt 0.70 ± 0.07 0.64 ± 0.08 0.64 ± 0.08 <0.001 a, b
Crs (mL/cmH2O) 29 ± 9 29 ± 9 32 ± 11 0.001 b, c
∆ Paw (cmH2O) 13.6 ± 3.6 13.4 ± 3.6 10.9 ± 3.1 <0.001 a, b, c
Raw (cmH2O/L/s) 14 ± 5 13 ± 5 13 ± 4 0.28  
pH 7.31 ± 0.07 7.34 ± 0.09 7.31 ± 0.08 <0.001 a, c
PaO2 (mmHg) 102 ± 23 98 ± 23 105 ± 29 0.35  
PaCO2 (mmHg) 54 ± 9 50 ± 8 54 ± 10 <0.001 a, c
EtCO2 (mmHg) 41 ± 6 39 ± 6 43 ± 7 0.002 a, c
P(a-et)CO2 (mmHg) 13 ± 6 12 ± 8 12 ± 9 0.27  
MAP (mmHg) 80 ± 12 76 ± 9 77 ± 12 0.08  
HR (beats/min) 87 ± 19 83 ± 20 86 ± 21 0.14  
Temperature (°C) 36.7 ± 0.9 36.7 ± 0.9 36.6 ± 0.8 0.61  
  1. Data are presented as number (%) or mean ± SD
  2. Intergroup differences (p < 0.05): a, phase 1 versus phase 2; b, phase 1 versus phase 3; c, phase 2 versus phase 3
  3. Crs static compliance of the respiratory system, EIP end-inspiratory pause, EtCO 2 end-tidal carbon dioxide concentration in the expired air, FiO 2 fraction of inspired oxygen, HR heart rate, MAP mean arterial pressure, PaO 2 partial pressure of oxygen in arterial blood, PaCO 2 partial pressure of carbon dioxide in arterial blood, PBW predicted body weight, PEEPi intrinsic positive end-expiratory pressure, Pmean mean airway pressure, Ppeak peak airway pressure, Pplat plateau airway pressure, P(a-et)CO2 arterial to end-tidal CO2 gradient, Raw airway resistance, Vd phys physiological dead space, Vd/Vt dead space-to-Vt ratio, Vt tidal volume, ∆Paw driving airway pressure