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Table 4 Serotonergic drug use

From: Unsuspected serotonin toxicity in the ICU

 

Suspected ST (n = 7)

No suspected ST (n = 54)

Number of serotonergic drugs concomitantly (n)

  

 None

0

17

 One

3

32

 Two or more

4

5

Fentanyl intravenously (n)

7

29

 Number of days continuous [mean (SD)]

6,9 (4,7)

5,6 (4,3)

 Cumulative dosage (mg) [mean (SD)]

18,5 (29,3)

14,2 (16,7)

Metoclopramide (n)

3

4

Tramadol (n)

1

1

Ondansetron (n)

1

6

CYP 3A4 inhibitor concomitantly (n)

4

12

CYP 2D6 inhibitor concomitantly (n)

3

21

 Both CYP 3A4 and 2D6 inhibitors (n)

3

8

  1. ST serotonin toxicity, n number, SD standard deviation, CYP 3A4 inhibitor cytochrome P450 3A4 iso-enzyme inhibitor, CYP2D6 inhibitor cytochrome P450 2D6 iso-enzyme inhibitor