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Table 4 Serotonergic drug use

From: Unsuspected serotonin toxicity in the ICU

  Suspected ST (n = 7) No suspected ST (n = 54)
Number of serotonergic drugs concomitantly (n)   
 None 0 17
 One 3 32
 Two or more 4 5
Fentanyl intravenously (n) 7 29
 Number of days continuous [mean (SD)] 6,9 (4,7) 5,6 (4,3)
 Cumulative dosage (mg) [mean (SD)] 18,5 (29,3) 14,2 (16,7)
Metoclopramide (n) 3 4
Tramadol (n) 1 1
Ondansetron (n) 1 6
CYP 3A4 inhibitor concomitantly (n) 4 12
CYP 2D6 inhibitor concomitantly (n) 3 21
 Both CYP 3A4 and 2D6 inhibitors (n) 3 8
  1. ST serotonin toxicity, n number, SD standard deviation, CYP 3A4 inhibitor cytochrome P450 3A4 iso-enzyme inhibitor, CYP2D6 inhibitor cytochrome P450 2D6 iso-enzyme inhibitor