Table 1 Baseline characteristics of 439 survivors and non-survivors with the acute respiratory distress syndrome in the Netherlands
Survivors (N = 252) | Non-survivors (N = 187; 43 %) | P | |
|---|---|---|---|
Gender, male, N (%) | 163 (64.7) | 120 (64.2) | 0.92 |
Age, mean ± SD | 58.5 ± 15.4 | 63.1 ± 12.7 | 0.001 |
Cause of ARDS, N (%) | |||
Pneumonia | 154 (61.1) | 115 (61.5) | 1.0 |
Aspiration | 25 (9.9) | 16 (8.6) | 0.76 |
Other pulmonary | 2 (0.8) | 1 (0.5) | 1.0 |
Sepsis | 144 (57.1) | 132 (70.6) | 0.003 |
Trauma | 38 (15.1) | 15 (8.0) | 0.029 |
Pancreatitis | 2 (0.8) | 6 (3.2) | 0.069 |
Other non-pulmonary | 29 (11.5) | 17 (9.1) | 0.43 |
Disease severity, mean ± SD | |||
APACHE IV | 85.5 ± 27 | 102.7 ± 30.7 | <0.001 |
SOFA score | 8.6 ± 3.2 | 10.1 ± 4.1 | <0.001 |
Physiological parameters, mean ± SD | |||
pH, median ± IQR | 7.4, 7.4–7.5 | 7.4, 7.3–7.4 | 0.001 |
PaCO2 | 42.1 ± 9 | 44.4 ± 12.1 | 0.039 |
PaO2/FiO2 | 126.8 ± 38.3 | 127.7 ± 43.1 | 0.81 |
Respiratory system compliance | 28.9 ± 15.6 | 37.4 ± 20.9 | <0.001 |
Ventilation parameters, mean ± SD | |||
Tidal volume (ml/kg PBW) | 7.7 ± 2 | 7.5 ± 1.7 | 0.38 |
FiO2 | 53.2 ± 12.9 | 56.7 ± 16.7 | 0.017 |
Respiratory rate | 22 ± 7 | 25 ± 8 | <0.001 |
PEEP (cmH2O) | 10.4 ± 3.6 | 10.9 ± 4 | 0.2 |
P max (cmH2O) | 26.2 ± 7.9 | 28.2 ± 9.4 | 0.018 |