Table 1 Study population according to hospital mortality (N (%)—median [IQR 25–75])
(N (%)—median [IQR 25–75]) | Alive at hospital discharge (n = 349) | Patients who died (n = 255, 42%) | p value |
|---|---|---|---|
Age (year) | 60 [50–69] | 61 [51–71] | 0.43 |
Malignancy | |||
Acute myeloid leukemia | 90 (25.8%) | 78 (30.6%) | 0.37 |
Non-Hodgkin lymphoma | 96 (27.5%) | 68 (26.7%) | |
Myeloma | 49 (14%) | 32 (12.5%) | |
Chronic lymphocytic leukemia | 32 (9.2%) | 23 (9%) | |
Acute lymphoblastic leukemia | 19 (5.4%) | 19 (7.4%) | |
Myelodysplastic syndrome | 18 (5.2%) | 12 (4.7%) | |
Hodgkin’s disease | 14 (4%) | 4 (1.6%) | |
Others | 31 (8.9%) | 19 (7.5%) | |
Disease status at admission | |||
Earliest phase | 120 (34.4%) | 88 (34.5%) | 0.86 |
Progression | 137 (39.3%) | 103 (40.4%) | |
Complete or partial remission | 83 (23.8%) | 55 (21.6%) | |
Unknown | 9 (2.5%) | 9 (3.5%) | |
Stem cell transplantation | |||
Autologous | 39 (11.2%) | 23 (9.1%) | 0.03 |
Allogeneic | 50 (14.3%) | 57 (22.4%) | |
Poor performance status | 55 (15.8%) | 69 (27.1%) | 0.001 |
Time from hospital to ICU admission >24 h | 159 (46%) | 96 (38%) | 0.061 |
Neutropenia | 85 (24.4%) | 97 (38%) | 0.0004 |
Respiratory rate at admission (/min) | 32 [25–37] | 35 [25–39] | 0.002 |
Invasive mechanical ventilation at day 1 | 107 (30.7%) | 143 (56.1%) | <0.0001 |
SOFA score >7 | 108 (32.2%) | 162 (66.7%) | <0.0001 |
ARF etiologies | |||
Infectious etiologies | 162 (46.4%) | 106 (41.6%) | <0.0001 |
Clinically documented | 60 (17.2%) | 21 (8.2%) | |
Bacterial infection | 56 (16%) | 54 (21.2%) | |
Viral infection | 16 (4.6%) | 8 (3.2%) | |
Other | 30 (8.6%) | 23 (9%) | |
Non-infectious lung involvement | 127 (36.4%) | 69 (27.1%) | |
Malignant infiltrate | 25 (7.2%) | 18 (7.1%) | |
Drug-related lung toxicity | 4 (1.1%) | 0 (0%) | |
Cardiac pulmonary edema | 48 (13.8%) | 17 (6.7%) | |
Other | 50 (14.3%) | 34 (13.3%) | |
Opportunistic infections | 28 (8%) | 34 (13.3%) | |
Invasive pulmonary aspergillosis | 6 (1.7%) | 24 (9.4%) | |
Pneumocystis jirovecii infections | 18 (5.1%) | 4 (1.6%) | |
Other invasive fungal infections | 3 (0.9%) | 2 (0.7%) | |
Other | 1 (0.3%) | 4 (1.6%) | |
Undetermined | 32 (9.2%) | 46 (18%) |