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Table 1 General characteristics, support measures and outcomes of patients

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

Variables Whole group
(N = 957)
Survivors
(N = 646)
Non-survivors
(N = 311)
P valuea
General characteristics
Age—yo 52 ± 19 50 ± 19 56 ± 18 <0.001
Gender (males/females)—n 504/453 331/315 173/138 0.291
SAPS 3 65 [50,79] 60 [48,72] 74 [59,90] <0.001
Total SOFA (first day) 6 [3,9] 5 [3,8] 9 [6,12] <0.001
Worst lactate (first day)—mmol/L 3.0 [2.0,4.0] 2.7 [1.9,3.7] 3.7 [2.2,5.8] <0.001
Maximum SOFA (ICU stay) 7 [6,12] 6 [5,9] 12 [8,16] <0.001
Support measures
Vasopressors—n (%) 572 (60) 322 (50) 250 (80) <0.001
Inotropes—n (%) 13 (1) 11 (2) 2 (1) <0.001
Mechanical ventilation (first day)—n (%) 259 (27) 131 (20) 128 (41) <0.001
(C)RRT (first day)—n (%) 102 (11) 51 (8) 51 (16) <0.001
Mechanical ventilation (ICU stay)—n (%) 420 (44) 267 (41) 153 (49) 0.026
(C)RRT (ICU stay)—n (%) 233 (24) 137 (21) 96 (31) 0.001
Sepsis-2 classification     
Sepsis—n (%) 134 (14) 116 (18) 18 (6) <0.001
Severe sepsis—n (%) 251 (26) 208 (32) 43 (14) <0.001
Septic shock—n (%) 572 (60) 322 (50) 250 (80) <0.001
Sepsis-3 classification     
No-dysfunction—n (%) 103 (11) 96 (15) 7 (2) <0.001
Sepsis—n (%) 419 (44) 313 (48) 106 (34) <0.001
Septic shock—n (%) 435 (45) 237 (37) 198 (64) <0.001
Infection source     
Respiratory—n (%) 402 (42) 263 (41) 139 (45) 0.271
Abdominal—n (%) 107 (11) 75 (12) 32 (10) 0.619
Urinary tract—n (%) 84 (9) 63 (10) 21 (7) 0.157
Skin and soft tissue—n (%) 72 (8) 45 (7) 27 (9) 0.417
Febrile neutropenia syndrome—n (%) 32 (3) 19 (3) 13 (4) 0.420
Catheter related—n (%) 22 (2) 17 (3) 5 (2) 0.448
Primary bloodstream infection—n (%) 17 (2) 13 (2) 4 (1) 0.592
Osteoarticular—n (%) 17 (2) 10 (2) 7 (2) 0.610
Unidentifiable source—n (%) 167 (17) 117 (18) 50 (16) 0.493
Othersbn (%) 37 (4) 24 (4) 13 (4) 1.000
Comorbidities     
Diabetes mellitus—n (%) 196 (20) 124 (19) 72 (23) 0.174
Chronic heart failure—n (%) 107 (11) 71 (11) 36 (12) 0.860
Chronic arterial hypertension—n (%) 95 (10) 61 (9) 34 (11) 0.534
Dialysis dependent chronic renal failure—n (%) 66 (7) 48 (7) 18 (6) 0.429
Rheumatologic diseases—n (%) 59 (6) 37 (6) 22 (7) 0.497
Chronic obstructive pulmonary disease—n (%) 38 (4) 25 (4) 13 (4) 0.949
Hematologic cancer—n (%) 30 (3) 11 (2) 19 (6) <0.001
Solid cancer—n (%) 26 (3) 17 (3) 9 (3) 0.977
Organ transplantation—n (%) 20 (2) 14 (2) 6 (2) 1.000
AIDScn (%) 19 (2) 12 (2) 7 (2) 0.867
Liver cirrhosis—n (%) 14 (1) 9 (1) 5 (2) 1.000
Outcomes     
Days on mechanical ventilationd 3 [1,6] 3 [1,6] 3 [1,4] 0.716
Days on (C)RRTd 3 [2,7] 3 [2,7] 3 [2,6] 0.181
Days on vasopressorsd 2 [1,4] 2 [1,4] 2 [1,4] 0.991
ICU Length of stay—days 5 [4,11] 5 [4,10] 6 [3,13] 0.994
ICU mortality—n (%) 311 (32) 0 (0) 311 (100) na
Death within the first 48 h of ICU—n (%) 78 (8) 0 (0) 78 (25) na
Discharge within the first 48 h of ICU—n (%) 85 (9) 85 (13) 0 (0) na
  1. aComparison between survivors and non-survivors
  2. bOthers are endocarditis, meningitis, leptospirosis and mediastinitis
  3. cAIDS denotes acquired immunodeficiency syndrome
  4. dResults using only patients which needed the support. na denotes not applicable