Skip to main content

Table 2 Multivariate models using ICU death as a dependent variable and sepsis definition and lactate as independent variables

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

 

Lactate as a continuous variable

Lactate > 2 mmol/L

Lactate > 4 mmol/L

OR (CI 95%)

P value

OR (CI 95%)

P value

OR (CI 95%)

P value

Sepsis-2 model

Sepsis

1

Reference

1

Reference

1

Reference

Severe sepsis

1.06 (0.97–1.16)

0.322

1.03 (1.01–1.19)

0.500

1.04 (0.95–1.19)

0.342

Septic shock

1.34 (1.22–1.44)

<0.001

1.33 (1.22–1.45)

0.001

1.32 (1.21–1.43)

0.001

Lactate

1.02 (1.02–1.03)

0.001

1.07 (1.00–1.14)

0.027

1.21 (1.14–1.30)

0.001

Sepsis-3 model

No-dysfunction

1

Reference

1

Reference

1

Reference

Sepsis

1.21 (1.11–1.34)

<0.001

1.19 (1.08–1.32)

<0.001

1.21 (1.10–1.14)

<0.001

Septic shock

1.41 (1.28–1.56)

<0.001

1.49 (1.35–1.65)

<0.001

1.41 (1.28–1.56)

<0.001

Lactate

1.02 (1.01–1.03)

<0.001

0.97 (0.90–1.05)

0.466

1.19 (1.11–1.28)

<0.001

  1. This analysis was performed using a binary logistic regression. The first model used lactate as a continuous variable (after logarithmic transformation in order to correct the positive skewness); the second and third models used lactate as a categorical variable
  2. Lactate > 2 mmol/L represents all patients with lactate > 2 mmol/L, including those with lactate > 4 mmol/L