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Table 2 Multivariate models using ICU death as a dependent variable and sepsis definition and lactate as independent variables

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

  Lactate as a continuous variable Lactate > 2 mmol/L Lactate > 4 mmol/L
OR (CI 95%) P value OR (CI 95%) P value OR (CI 95%) P value
Sepsis-2 model
Sepsis 1 Reference 1 Reference 1 Reference
Severe sepsis 1.06 (0.97–1.16) 0.322 1.03 (1.01–1.19) 0.500 1.04 (0.95–1.19) 0.342
Septic shock 1.34 (1.22–1.44) <0.001 1.33 (1.22–1.45) 0.001 1.32 (1.21–1.43) 0.001
Lactate 1.02 (1.02–1.03) 0.001 1.07 (1.00–1.14) 0.027 1.21 (1.14–1.30) 0.001
Sepsis-3 model
No-dysfunction 1 Reference 1 Reference 1 Reference
Sepsis 1.21 (1.11–1.34) <0.001 1.19 (1.08–1.32) <0.001 1.21 (1.10–1.14) <0.001
Septic shock 1.41 (1.28–1.56) <0.001 1.49 (1.35–1.65) <0.001 1.41 (1.28–1.56) <0.001
Lactate 1.02 (1.01–1.03) <0.001 0.97 (0.90–1.05) 0.466 1.19 (1.11–1.28) <0.001
  1. This analysis was performed using a binary logistic regression. The first model used lactate as a continuous variable (after logarithmic transformation in order to correct the positive skewness); the second and third models used lactate as a categorical variable
  2. Lactate > 2 mmol/L represents all patients with lactate > 2 mmol/L, including those with lactate > 4 mmol/L