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Table 3 Multivariate models using ICU death as a dependent variable and Sepsis-3 definition, lactate, age, SAPS 3 and requirement for RRT and mechanical ventilation as independent variables

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

  Lactate as a continuous variable Lactate > 2 mmol/L Lactate > 4 mmol/L
OR (CI 95%) P value OR (CI 95%) P value OR (CI 95%) P value
Sepsis-3 model
No-dysfunction 1 Reference 1 Reference 1 Reference
Sepsis 3.70 (1.75–9.12) 0.002 3.35 (1.57–8.27) 0.004 3.67 (1.73–9.07) 0.002
Septic shock 6.21 (2.94–15.27) <0.001 7.31 (3.41–18.22) <0.001 6.22 (2.94–15.31) <0.001
Lactate 1.11 (1.06–1.16) <0.001 0.94 (0.60–1.48) 0.811 2.28 (1.61–3.24) <0.001
Age 1.01 (1.01–1.02) <0.001 1.01 (1.01–1.02) 0.002 1.01 (1.00–1.02) <0.001
SAPS 3 1.02 (1.01–1.03) <0.001 1.02 (1.01–1.03) <0.001 1.02 (1.01–1.03) <0.001
RRTa 1.63 (1.15–2.31) 0.006 1.56 (1.11–2.21) 0.011 1.66 (1.17–2.36) 0.004
Mechanical ventilationa 1.29 (0.95–1.76) 0.107 1.26 (0.92–1.71) 0.146 1.27 (0.93–1.73) 0.131
  AUCb
(CI 95%)
Asymptotic
P value
AUCb
(CI 95%)
Asymptotic
P value
AUCb
(CI 95%)
Asymptotic
P value
Model accuracy 0.732 (0.698–0.766) <0.001 0.725 (0.691–0.759) <0.001 0.732 (0.698–0.766) <0.001
  1. aSupport needed at any time of ICU stay; RRT renal replacement therapy; SAPS Simplified Acute Physiological Score
  2. bAUC area under the curve