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Table 3 Multivariate models using ICU death as a dependent variable and Sepsis-3 definition, lactate, age, SAPS 3 and requirement for RRT and mechanical ventilation as independent variables

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

 

Lactate as a continuous variable

Lactate > 2 mmol/L

Lactate > 4 mmol/L

OR (CI 95%)

P value

OR (CI 95%)

P value

OR (CI 95%)

P value

Sepsis-3 model

No-dysfunction

1

Reference

1

Reference

1

Reference

Sepsis

3.70 (1.75–9.12)

0.002

3.35 (1.57–8.27)

0.004

3.67 (1.73–9.07)

0.002

Septic shock

6.21 (2.94–15.27)

<0.001

7.31 (3.41–18.22)

<0.001

6.22 (2.94–15.31)

<0.001

Lactate

1.11 (1.06–1.16)

<0.001

0.94 (0.60–1.48)

0.811

2.28 (1.61–3.24)

<0.001

Age

1.01 (1.01–1.02)

<0.001

1.01 (1.01–1.02)

0.002

1.01 (1.00–1.02)

<0.001

SAPS 3

1.02 (1.01–1.03)

<0.001

1.02 (1.01–1.03)

<0.001

1.02 (1.01–1.03)

<0.001

RRTa

1.63 (1.15–2.31)

0.006

1.56 (1.11–2.21)

0.011

1.66 (1.17–2.36)

0.004

Mechanical ventilationa

1.29 (0.95–1.76)

0.107

1.26 (0.92–1.71)

0.146

1.27 (0.93–1.73)

0.131

 

AUCb

(CI 95%)

Asymptotic

P value

AUCb

(CI 95%)

Asymptotic

P value

AUCb

(CI 95%)

Asymptotic

P value

Model accuracy

0.732 (0.698–0.766)

<0.001

0.725 (0.691–0.759)

<0.001

0.732 (0.698–0.766)

<0.001

  1. aSupport needed at any time of ICU stay; RRT renal replacement therapy; SAPS Simplified Acute Physiological Score
  2. bAUC area under the curve