Skip to main content

Table 4 Predictive accuracy of mortality of sepsis definitions with or without lactate value

From: Sepsis-3 definitions predict ICU mortality in a low–middle-income country

  Sepsis-2 definition Sepsis-3 definition
AUC (CI 95%) Asymptotic P value AUC (CI 95%) Asymptotic P value
Without lactate model 0.650 (0.619–0.680) <0.001 0.615 (0.580–0.650) <0.001
Lactate as a continuous variablea 0.704 (0.668–0.739)b <0.001 0.649 (0.608–0.689)b, d <0.001
Lactate > 2 mmol/L 0.664 (0.631–0.697) <0.001 0.620 (0.584–0.656) <0.001
Lactate > 4 mmol/L 0.686 (0.653–0.719)b, c, d <0.001 0.636 (0.598–0.674)b, c, d <0.001
  1. The receiver operating curves (ROC) were constructed using the binary logistic regression probabilities of death using sepsis definitions and lactate categories. AUC area under the ROC curve
  2. aLactate as a continuous variable was logarithmically transformed in order to correct the positive skewness. Lactate > 2 mmol/L represents all patients with lactate > 2 mmol/L, including those with lactate > 4 mmol/L
  3. bDeLong’s test P < 0.05 versus without lactate model
  4. cDeLong’s test P = ns versus lactate as a continuous variable
  5. dDeLong’s test P < 0.05 versus lactate > 2 mmol/L