Skip to main content

Table 2 Data on lung mechanics, hemodynamics and metrics for oxygenation and gas exchange in N = 22 pediatric patients with acute hypoxemic respiratory failure (a) all patients and (b) mild versus moderate-to-severe PARDS

From: Short-term effects of neuromuscular blockade on global and regional lung mechanics, oxygenation and ventilation in pediatric acute hypoxemic respiratory failure

 

All patients (N = 22)

Before

During

(a)

Lung mechanics

 P plat (cmH2O)

28 (26–33)

29 (26–30)

 mPaw (cmH2O)

14 (13–16)

14 (13–15)*

 Driving pressure (V T/Crs) (cmH2O)

15.7 (11.6–22.9)

16.4 (7.9–19.4)

 Plat–PEEP (cmH2O)

22 (17–26)

21 (19–23)

 PEEP (cmH2O)

8 (6–10)

8 (6–10)

 Respiratory rate (/min)a

40 (34–43)

35 (30–40)*

 Compliance (mL/cmH2O/kg)

0.51 (0.34–0.77)

0.45 (0.38–0.87)

 Resistance (cmH2O/L/kg/s)

26.2 (5.5–40.6)

24.5 (6.5–31.3)

Hemodynamics

 Heart rate (/min)

155 (126–170)

162 (137–176)

 Mean arterial pressure (mmHg)

63 (56–73)

60 (50–69)

Metrics for oxygenation and gas exchange

 PaO2 (mmHg)

65 (58–102)

76 (66–103)

 PaCO2 (mmHg)

48 (44–56)

51 (44–61)

 End-tidal CO2 (mmHg)

39 (35–46)

39 (35–46)

 pH

7.35 (7.30–7.40)

7.34 (7.22–7.39)

 Oxygenation index

12.8 (7.5–16.9)

10.2 (7.8–14.5)*

 PaO2/FiO2 ratio

104 (90–168)

133 (95–172)

 SpO2/FiO2 ratio

150 (115–186)

142 (111–178)

 AVDSF

0.19 (0.10–0.28)

0.22 (0.14–0.34)**

 

Mild PARDS (N = 6)

Moderate or severe PARDS (N = 16)

Before

During

Before

During

(b)

Lung mechanics

 P plat (cmH2O)

28 (23–29)

29 (24–32)

30 (26–35)

29 (26–30)

 mPaw (cmH2O)

13 (10–15)

13 (10–14)

15 (13–16)

14 (13–16)

 Driving pressure (V T/Crs) (cmH2O)

18.3 (10.6–26.8)

17.1 (7.1–19.7)

15.0 (10.0–22.6)

18.3 (12.5–21.4)

 Plat–PEEP (cmH2O)

20 (14–24)

21 (17–26)

22 (17–28)

21 (18–23)

 PEEP (cmH2O)

6.5 (5–8.5)

6.5 (5–8.5)

8 (7.3–10)

8 (7.3–10)

 Respiratory rate (/min)a

35 (29–50)

35 (23–46)*

40 (33–43)

38 (30–40)

 Compliance (mL/cmH2O/kg)

0.66 (0.46–0.98)

1.16 (0.41–1.81)

0.50 (0.31–0.70)

0.45 (0.37–0.82)

 Resistance (cmH2O/L/kg/s)

15.8 (3.7–47.6)

16.0 (2.9–42.0)

26.2 (8.9–41.3)

24.5 (10.3–31.3)

Hemodynamics

 Heart rate (/min)

152 (113–191)

155 (111–188)

155 (139–163)

162 (140–173)*

 Mean arterial pressure (mmHg)

71 (60–76)

63 (53–77)

60 (55–71)

58 (49–69)

Metrics for oxygenation and gas exchange

 PaO2 (mmHg)

128 (99–188)

102 (74–216)

62 (56–72)

70 (63–90)*

 PaCO2 (mmHg)

50 (42–59)

53 (42–65)

45 (44–58)

51 (44–61)

 End-tidal CO2 (mmHg)

39 (34–49)

41 (31–49)

39 (34–46)

39 (35–44)

 pH

7.34 (7.21–7.44)

7.33 (7.25–7.39)

7.36 (7.32–7.40)

7.34 (7.19–7.40)

 Oxygenation index

4.5 (4.0–7.2)

6.1 (4.9–7.5)

15.2 (12.2–23.3)

12.5 (10.0–19.1)*

 PaO2/FiO2 ratio

286 (164–337)

207 (151–272)

100 (81–117)

109 (87–154)*

 SpO2/FiO2 ratio

193 (115–246)

165 (121–216)

141 (105–175)

135 (105–177)

 AVDSF

0.20 (0.12–0.31)

0.24 (0.14–0.32)

0.17 (0.06–0.26)

0.22 (0.14–0.35)**

  1. Data are expressed as median (25–75 interquartile range)
  2. PARDS pediatric acute respiratory distress syndrome, P plat plateau pressure, mPaw mean airway pressure, V T tidal volume measured by the ventilator; respiratory system compliance, AVDSF end-tidal alveolar dead space fraction
  3. * p < 0.05; ** p < 0.01 on paired analysis (before neuromuscular blockade vs during neuromuscular blockade)
  4. aRespiratory rate is the machine breaths and spontaneous breaths