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TableĀ 4 Anti-CMV medications and common associated side effects

From: Cytomegalovirus infection in immunocompetent critically ill adults: literature review

Agent Mechanism of action Common side effects
Ganciclovir Competitively inhibits the binding of deoxyguanosine triphosphate to DNA polymerase resulting in inhibition of viral DNA synthesis Thrombocytopenia, leukopenia, increased creatinine, fever, vomiting, diarrhea
Valganciclovir Converted to ganciclovir in the body, much higher bioavailability of ganciclovir compared to oral ganciclovir As ganciclovir
Foscarnet Non-competitive inhibitor of many viral RNA and DNA polymerases Electrolyte abnormalities, fever, vomiting, diarrhea, anemia, granulocytopenia, renal insufficiency, cardiotoxicity, central nervous system toxicity, hepatic toxicity
Cidofovir Suppresses CMV replication by selective inhibition of viral DNA synthesis Fever, alopecia, rash, ocular, renal, and gastrointestinal toxicity, cough, dyspnea