Surgical ICU patients
| | | | | | | | | | | | | | |
Lago Borges et al.
|
2014
|
Post-CG
|
136b
|
44
|
10
|
08
|
No
|
0.47
|
45
|
05
|
08
|
No
|
0.47
|
Shorter duration of ventilation with higher PEEP (considering only patients extubated within 12 h after ICU admission)
|
Lago Borges et al.
|
2013
|
Post-CG
|
136b
|
44
|
10
|
08
|
No
|
0.47
|
45
|
05
|
08
|
No
|
0.47
|
Higher compliance and less hypoxemia (P/F ratio < 300) with higher PEEP
|
Celebi et al.
|
2007
|
Post-CG
|
60a
|
20
|
10
|
07
|
Yes
|
0.25
|
20
|
05
|
07
|
No
|
0.25
|
Increase in P/F ratio (in the first 4 h but not after extubation) and less atelectasis with higher PEEP
|
Holland et al.
|
2007
|
Post-CG
|
28
|
14
|
10
|
6–8
|
No
|
0.08
|
14
|
05
|
6–8
|
No
|
0.08
|
No differences regarding cardiac index and filling pressures, liver function and gastric mucosal perfusion
|
Dyhr et al.
|
2002
|
Post-CG
|
16
|
08
|
15
|
06
|
Yes
|
NA
|
08
|
00
|
06
|
Yes
|
NA
|
Increase in P/F ratio and EELV (in the first 3 h) and less atelectasis with higher PEEP
|
Michalopoulos et al.
|
1996
|
Post-CG
|
67d
|
21
|
10
|
NA
|
No
|
NA
|
22
|
00
|
NA
|
No
|
NA
|
No differences regarding P/F ratio, duration of ventilation, and atelectasis
|
Carroll et al.
|
1988
|
Postsurgery P/F < 200
|
50
|
22
|
15
|
12
|
Yes
|
15
|
28
|
04
|
12
|
Yes
|
02
|
More hypotension, barotrauma, and death and higher duration of ventilation with higher PEEP
|
Marvel et al.
|
1986
|
Post-CG
|
44c
|
12
|
10
|
12
|
No
|
0.39
|
15
|
05
|
12
|
No
|
0.46
|
Lower alveolar–arterial oxygen tension gradient with higher PEEP (similar after extubation). No differences regarding atelectasis, and hospital length of stay
|
Murphy et al.
|
1983
|
Post-CG
|
139
|
NA
|
10
|
NA
|
No
|
0.33
|
NA
|
00
|
NA
|
No
|
0.33
|
No differences in blood loss independent of coagulation profile
|
Zurick et al.
|
1982
|
Post-CG
|
83
|
41
|
10
|
NA
|
No
|
NA
|
42
|
00
|
NA
|
No
|
NA
|
No differences regarding the amount of blood loss, need for re-exploration or blood requirement
|
Good et al.
|
1979
|
Post-CG
|
24
|
10
|
06
|
11
|
No
|
0.62
|
14
|
00
|
11
|
No
|
0.62
|
No differences regarding atelectasis, P/F ratio and arterial–alveolar ratio
|
Schmidt et al.
|
1976
|
Post-surgery risk of ARDS
|
112
|
56
|
08
|
12–15
|
No
|
NA
|
56
|
00
|
12–15
|
Yes
|
NA
|
Higher PaO2, alveolar–arterial oxygen tension, and lower incidence of ARDS and other pulmonary complications with higher PEEP
|
Medical
| | | | | | | | | | | | | | |
Ma et al.
|
2014
|
NPE
|
120
|
60
|
11–30
|
6–8
|
No
|
NA
|
60
|
3–10
|
6–8
|
No
|
NA
|
Lower 28-day mortality, EVLWi, PVPi, blood pressure and higher P/F ratio with high PEEP
|
Lesur et al.
|
2010
|
ARF
|
63
|
30
|
05
|
08
|
No
|
9.2
|
33
|
00
|
07
|
No
|
9.2
|
No differences regarding hypotension, duration of ventilation and mortality (PEEP used only during 90 min)
|
Manzano et al.
|
2008
|
Clinical P/F > 250
|
127
|
64
|
5–8
|
08
|
No
|
4.5
|
63
|
00
|
08
|
No
|
5.6
|
No differences regarding hospital mortality, ARDS, atelectasis or barotrauma. Lower incidence of VAP and hypoxemia with high PEEP
|
Vigil et al.
|
1996
|
Trauma
|
44
|
23
|
05
|
12
|
No
|
3.2
|
21
|
00
|
12
|
No
|
3.6
|
No differences regarding intrapulmonary shunt, dead space and P/F ratio
|
Cujec et al.
|
1993
|
ARF
|
46
|
NA
|
10
|
NA
|
No
|
NA
|
NA
|
00
|
NA
|
No
|
NA
|
Reduction in alveolar–arterial oxygen difference and shunt fraction with higher PEEP
|
Nelson et al.
|
1987
|
P/F < 250
|
38
|
20
|
15
|
NA
|
No
|
5.3
|
18
|
08
|
NA
|
No
|
3.4
|
No differences in duration of ventilation, ICU and hospital length of stay, barotrauma, and mortality
|
Pepe et al.
|
1984
|
Risk of ARDS
|
92
|
44
|
08
|
12
|
No
|
3.0
|
48
|
00
|
12
|
No
|
3.0
|
No differences regarding ARDS, barotrauma, atelectasis, mortality, duration of ventilation, ICU length of stay
|
Weigelt et al.
|
1979
|
Risk of ARDS
|
79
|
45
|
05
|
15
|
No
|
5.0
|
34
|
00
|
15
|
No
|
8.0
|
Lower incidence of ARDS, and pulmonary mortality and higher incidence of pulmonary dysfunction with higher PEEP
|
Feeley et al.
|
1975
|
ARF
|
25
|
12
|
05
|
10
|
No
|
NA
|
13
|
00
|
10
|
No
|
NA
|
Improve in vital capacity and the maximum inspiratory force and less increase in intra-pulmonary shunt with higher PEEP
|