Patients | Ventilated controls (n = 14) | Mild (n = 1) and moderate (n = 6) ARDS | Severe ARDS (n = 10) | p value |
---|---|---|---|---|
Age (years, median ± IQR) | 56 ± 19 | 52 ± 24 | 59 ± 6 | 0.82 |
Male/female (number) | 9/5 | 6/1 | 7/3 | 0.78 |
Comorbidities | ||||
Smoking (number, percentage) | 4 (29%) | 5 (71%) | 2 (20%) | 0.07 |
Obstructive airway diseases (number, percentage) | 5 (36%) | 5 (71%) | 4 (40%) | 0.27 |
Cardiovascular disease (number, percentage) | 1 (7%) | 1 (14%) | – | 0.49 |
Diabetes (number, percentage) | 2 (14%) | 1 (14%) | – | 0.45 |
Malignancy (number, percentage) | – | 1 (14%) | 1 (10%) | 0.39 |
Reasons for ICU admission | ||||
Sepsis (number, percentage) | 7 (50%) | 6 (86%) | 8 (80%) | 0.15 |
Pneumonia (number, percentage) | 5 (36%) | 5 (71%) | 5 (50%) | 0.30 |
Postoperative care (number, percentage) | 11 (79%) | 7 (100%) | 9 (90%) | 0.36 |
Congestive heart failure (number, percentage) | 2 (14%) | 1 (14%) | – | 0.45 |
Hemorrhagic shock (number, percentage) | 1 (14%) | 2 (29%) | – | 0.13 |
Trauma (number, percentage) | 4 (29%) | 1 (14%) | 3 (30%) | 0.73 |
SAPS II (median ± IQR) | 39.0 ± 13.5 | 45.0 ± 21.0 | 43.5 ± 20.5 | 0.67 |
SOFA at inclusion (median ± IQR) | 6 ± 4 | 7 ± 2 | 7.5 ± 3.5 | 0.06 |
CRP at inclusion (mg/L, median ± IQR) | 217 ± 325 | 211 ± 195 | 273 ± 313 | 0.80 |
Number of samples per patient (range) | 1–5 | 1–5 | 1–9 | – |
Cause of lung injury | ||||
Pneumonia at inclusion (number, percentage) | 5 (36%) | 5 (71%) | 8 (80%) | 0.081 |
Aspiration (number, percentage) | 1 (7%) | 2 (29%) | 3 (30%) | 0.29 |
Septic shock at inclusion (number, percentage) | 5 (36%) | 6 (86%) | 8 (80%) | 0.043 |
Extra pulmonary cause (number, percentage) | – | 3 (43%) | 2 (20%) | 0.038 |
Steroid therapya (number, percentage) | 1 (7%) | 1 (14%) | 5 (50%) | 0.051 |
Vasoactive agent therapya (number, percentage) | 7 (50%) | 7 (100%) | 6 (60%) | 0.065 |
Lung injury score at inclusion (median ± IQR) | 0.67 ± 0.91 | 2.33 ± 0.66 | 3.00 ± 0.72 | <0.0001 |
Respiratory variables | ||||
Positive end-expiratory pressure, cmH20 (median ± IQR) | 5 ± 0.5 | 8 ± 1 | 9 ± 2 | 0.001 |
PaO2/FiO2 at inclusion mmHg (median ± IQR) | 253 ± 85 | 210 ± 49 | 67 ± 29 | <0.0001 |
PaCO2 at inclusion mmHg (median ± IQR) | 41 ± 5 | 43 ± 4 | 43 ± 4 | 0.72 |
ECMOa (number, percentage) | – | – | 6 (60%) | 0.0004 |
Mortality at day 28 (number, percentage) | 4 (28%) | 2 (29%) | 6 (60%) | 0.26 |