From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock
Characteristics | Survivors (n = 64) | Non-survivors (n = 46) | P |
---|---|---|---|
At ICU admission | |||
Age (years old) | 60 [45–69] | 63 [57–73] | 0.03 |
Male sex | 49 (76.6) | 29 (63) | 0.12 |
Weight (kg) | 70 [60–80] | 70 [58–79] | 0.84 |
Body mass index (kg/m2) | 24.6 [20.7–27.8] | 24.4 [20.7–28] | 0.58 |
APACHE II | 21 [17–25] | 26 [22–29] | 0.0007 |
Simplified Acute Physiology Score 2 | 52 [41–60] | 57 [45–73] | 0.05 |
History of congestive heart failure | 6 (9.4) | 6 (13) | 0.54 |
Liver cirrhosis | 0 | 4 (8.7) | 0.03 |
Chronic obstructive pulmonary disease | 15 (23.4) | 11 (23.9) | 0.96 |
Chronic kidney disease requiring dialysis | 4 (6.3) | 5 (10.9) | 0.38 |
Cancer (<3 months) | 11 (17.2) | 5 (10.9) | 0.35 |
Diabetes mellitus | 15 (23.4) | 24 (52.2) | 0.002 |
Immunodepression | 16 (25) | 8 (17.4) | 0.34 |
At the day of aminoglycoside administration | |||
Day since admission | 1 [0–5] | 2 [0–7] | 0.32 |
Emergent surgery | 17 (26.6) | 8 (17.4) | 0.26 |
Sequential Organ Failure Assessment score | 9 [7–10] | 10 [9–13] | 0.004 |
Weight (kg) | 70 [60–81] | 70.5 [60–80] | 0.92 |
Weight gain since ICU admission (kg) | 0 [0–2] | 0 [0–3] | 0.62 |
Extracorporeal membrane oxygenation | 7 (10.9) | 8 (17.4) | 0.33 |
Catecholamines | 49 (76.6) | 40 (87) | 0.17 |
Norepinephrine (µg/kg/min) | 0.26 [0.04–0.61] | 0.83 [0.41–1.65] | 0.0002 |
PaO2/FiO2 ratio | 200 [140–280] | 147 [103–259] | 0.06 |
Renal replacement therapy | 19 (29.7) | 21 (45.7) | 0.09 |
Glomerular filtration rate (mL/min) | 53.5 [29.7–90.4] | 29.8 [0–65.9] | 0.008 |
Lactate level (mmol/L) | 1.7 [1.2–3.1] | 3.2 [1.4–7] | 0.01 |
Platelet count (G/L) | 205 [105–339] | 201 [86–270] | 0.47 |
Hematocrit level (%) | 29.2 [26–31.3] | 29.7 [26–32.4] | 0.54 |
Leucocyte count (G/L) | 15.6 [9.4–22.3] | 13.4 [7.8–18.7] | 0.22 |
Glasgow Coma Scale score | 15 [14, 15] | 15 [12–15] | 0.23 |
Bilirubin level (mg/dL) | 12 [8–17] | 145 [9–26] | 0.22 |
Prothrombin time (%) | 72 [57–81] | 60 [47–75] | 0.01 |
Proteinemia (g/L) | 58 [49–64] | 52 [46–62] | 0.1 |
Amikacin C max between 60 and 80 mg/L | 34 (53.1) | 13 (28.3) | 0.009 |