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Table 2 Baseline patient characteristics at intensive care unit admission and at inclusion (survivors/non-survivors)

From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

Characteristics

Survivors (n = 64)

Non-survivors (n = 46)

P

At ICU admission

 Age (years old)

60 [45–69]

63 [57–73]

0.03

 Male sex

49 (76.6)

29 (63)

0.12

 Weight (kg)

70 [60–80]

70 [58–79]

0.84

 Body mass index (kg/m2)

24.6 [20.7–27.8]

24.4 [20.7–28]

0.58

 APACHE II

21 [17–25]

26 [22–29]

0.0007

 Simplified Acute Physiology Score 2

52 [41–60]

57 [45–73]

0.05

 History of congestive heart failure

6 (9.4)

6 (13)

0.54

 Liver cirrhosis

0

4 (8.7)

0.03

 Chronic obstructive pulmonary disease

15 (23.4)

11 (23.9)

0.96

 Chronic kidney disease requiring dialysis

4 (6.3)

5 (10.9)

0.38

 Cancer (<3 months) 

11 (17.2)

5 (10.9)

0.35

 Diabetes mellitus

15 (23.4)

24 (52.2)

0.002

 Immunodepression

16 (25)

8 (17.4)

0.34

At the day of aminoglycoside administration

 Day since admission

1 [0–5]

2 [0–7]

0.32

 Emergent surgery

17 (26.6)

8 (17.4)

0.26

 Sequential Organ Failure Assessment score

9 [7–10]

10 [9–13]

0.004

 Weight (kg)

70 [60–81]

70.5 [60–80]

0.92

 Weight gain since ICU admission (kg)

0 [0–2]

0 [0–3]

0.62

 Extracorporeal membrane oxygenation

7 (10.9)

8 (17.4)

0.33

 Catecholamines

49 (76.6)

40 (87)

0.17

 Norepinephrine (µg/kg/min)

0.26 [0.04–0.61]

0.83 [0.41–1.65]

0.0002

 PaO2/FiO2 ratio

200 [140–280]

147 [103–259]

0.06

 Renal replacement therapy

19 (29.7)

21 (45.7)

0.09

 Glomerular filtration rate (mL/min)

53.5 [29.7–90.4]

29.8 [0–65.9]

0.008

 Lactate level (mmol/L)

1.7 [1.2–3.1]

3.2 [1.4–7]

0.01

 Platelet count (G/L)

205 [105–339]

201 [86–270]

0.47

 Hematocrit level (%)

29.2 [26–31.3]

29.7 [26–32.4]

0.54

 Leucocyte count (G/L)

15.6 [9.4–22.3]

13.4 [7.8–18.7]

0.22

 Glasgow Coma Scale score

15 [14, 15]

15 [12–15]

0.23

 Bilirubin level (mg/dL)

12 [8–17]

145 [9–26]

0.22

 Prothrombin time (%)

72 [57–81]

60 [47–75]

0.01

 Proteinemia (g/L)

58 [49–64]

52 [46–62]

0.1

 Amikacin C max between 60 and 80 mg/L

34 (53.1)

13 (28.3)

0.009

  1. Results are expressed as the median [25th–75th percentiles] or n (%) as appropriate
  2. APACHE Acute Physiology and Chronic Health Evaluation, C max peak plasma concentration, PaO 2 /FiO 2 partial pressure of oxygen in arterial blood/fraction of inspired oxygen