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Table 2 Baseline patient characteristics at intensive care unit admission and at inclusion (survivors/non-survivors)

From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

Characteristics Survivors (n = 64) Non-survivors (n = 46) P
At ICU admission
 Age (years old) 60 [45–69] 63 [57–73] 0.03
 Male sex 49 (76.6) 29 (63) 0.12
 Weight (kg) 70 [60–80] 70 [58–79] 0.84
 Body mass index (kg/m2) 24.6 [20.7–27.8] 24.4 [20.7–28] 0.58
 APACHE II 21 [17–25] 26 [22–29] 0.0007
 Simplified Acute Physiology Score 2 52 [41–60] 57 [45–73] 0.05
 History of congestive heart failure 6 (9.4) 6 (13) 0.54
 Liver cirrhosis 0 4 (8.7) 0.03
 Chronic obstructive pulmonary disease 15 (23.4) 11 (23.9) 0.96
 Chronic kidney disease requiring dialysis 4 (6.3) 5 (10.9) 0.38
 Cancer (<3 months)  11 (17.2) 5 (10.9) 0.35
 Diabetes mellitus 15 (23.4) 24 (52.2) 0.002
 Immunodepression 16 (25) 8 (17.4) 0.34
At the day of aminoglycoside administration
 Day since admission 1 [0–5] 2 [0–7] 0.32
 Emergent surgery 17 (26.6) 8 (17.4) 0.26
 Sequential Organ Failure Assessment score 9 [7–10] 10 [9–13] 0.004
 Weight (kg) 70 [60–81] 70.5 [60–80] 0.92
 Weight gain since ICU admission (kg) 0 [0–2] 0 [0–3] 0.62
 Extracorporeal membrane oxygenation 7 (10.9) 8 (17.4) 0.33
 Catecholamines 49 (76.6) 40 (87) 0.17
 Norepinephrine (µg/kg/min) 0.26 [0.04–0.61] 0.83 [0.41–1.65] 0.0002
 PaO2/FiO2 ratio 200 [140–280] 147 [103–259] 0.06
 Renal replacement therapy 19 (29.7) 21 (45.7) 0.09
 Glomerular filtration rate (mL/min) 53.5 [29.7–90.4] 29.8 [0–65.9] 0.008
 Lactate level (mmol/L) 1.7 [1.2–3.1] 3.2 [1.4–7] 0.01
 Platelet count (G/L) 205 [105–339] 201 [86–270] 0.47
 Hematocrit level (%) 29.2 [26–31.3] 29.7 [26–32.4] 0.54
 Leucocyte count (G/L) 15.6 [9.4–22.3] 13.4 [7.8–18.7] 0.22
 Glasgow Coma Scale score 15 [14, 15] 15 [12–15] 0.23
 Bilirubin level (mg/dL) 12 [8–17] 145 [9–26] 0.22
 Prothrombin time (%) 72 [57–81] 60 [47–75] 0.01
 Proteinemia (g/L) 58 [49–64] 52 [46–62] 0.1
 Amikacin C max between 60 and 80 mg/L 34 (53.1) 13 (28.3) 0.009
  1. Results are expressed as the median [25th–75th percentiles] or n (%) as appropriate
  2. APACHE Acute Physiology and Chronic Health Evaluation, C max peak plasma concentration, PaO 2 /FiO 2 partial pressure of oxygen in arterial blood/fraction of inspired oxygen