Table 4 Amikacin pharmacokinetic/pharmacodynamic parameters
From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock
Variable | n = 110 |
|---|---|
Dose (mg) | 2100 [1800–2400] |
Dose (mg/kg) | 30 [29.2–30.6] |
Peak plasma concentration (mg/L) | 75 [66.1–86.1] |
Patients with a peak concentration >80 mg/L | 44 (40) |
Patients with a peak concentration between 60 and 80 mg/L | 46 (41.8) |
Patients with a peak concentration <60 mg/L | 20 (18.2) |
Patients with a peak concentration <30 mg/L | 0 |
Trough concentration >2.5 mg/La | 51 (78.5) |