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Table 4 Amikacin pharmacokinetic/pharmacodynamic parameters

From: Impact of a high loading dose of amikacin in patients with severe sepsis or septic shock

Variable n = 110
Dose (mg) 2100 [1800–2400]
Dose (mg/kg) 30 [29.2–30.6]
Peak plasma concentration (mg/L) 75 [66.1–86.1]
Patients with a peak concentration >80 mg/L 44 (40)
Patients with a peak concentration between 60 and 80 mg/L 46 (41.8)
Patients with a peak concentration <60 mg/L 20 (18.2)
Patients with a peak concentration <30 mg/L 0
Trough concentration >2.5 mg/La 51 (78.5)
  1. Results are expressed as the median [25th–75th percentiles] or n (%)
  2. aTrough concentration was not measured for 45 patients