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Table 1 Baseline characteristics of the patients in the two cohorts

From: Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial

  Learning cohort (northern) N = 405 Validating cohort (southern) N = 353
Age (year) (median, IQR) 68 (59–77) 67 (57–75)
Apache II score (median, IQR) 21 (15–28) 19 (14–25)
Body mass index (kg/m2, median, IQR) 24.7 (22.8–27.7) 24.7 (22.2–27.7)
eGFR (ml/min/1.73 m2) 48.5 (26.4–78.9) 58.8 (33.5–93.5)
PaO2/FiO2 (Kpa, median, IQR) 19.4 (11.6–29.2) 21 (13.6–28.9)
Surfactant protein D (ng/mL, median, IQR) 133.5 (77.3–308.0) 112 (63.5–240.7)
Club cell secretory protein 16 (ng/mL, median, IQR) 25.4 (10.6–37.4) 20.2 (7.7–37.9)
Severe sepsis/septic shock, n (%) 158 (39.0) 149 (42.2)
Charlson’s comorbidity index, n (%)
 0 130 (32.1) 136 (38.5)
 1 139 (34.3) 108 (30.6)
 2 79 (19.5) 65 (18.4)
 3 34 (8.4) 30 (8.5)
 4 13 (3.2) 8 (2.3)
 5 6 (1.5) 2 (0.6)
 6 4 (1.0) 3 (0.9)
 7 0 (0.0) 1 (0.3)
COPD, n (%) 81 (20.0) 75 (21.3)
Primary admittance cause/acute diagnosis category (%)
 Pneumonia 137 (33.8) 117 (33.1)
 Abdominal sepsis 65 (16.1) 76 (21.5)
 Sepsis of other cause 48 (11.9) 42 (11.9)
 Heart failure 47 (11.6) 34 (9.6)
 Thrombosis or bleeding 52 (12.8) 20 (5.7)
 Other 56 (13.8) 64 (18.1)
Gender, n (%)   
 Female 184 (45.4) 163 (46.2)
 Male 221 (54.6) 190 (53.8)
  1. y, years; IQR, interquartile range; COPD, chronic obstructive pulmonary disease; eGFR, estimated glomerular filtration rate—calculated by the Cockroft–Gault formula