Table 1 Baseline characteristics of the patients in the two cohorts
Learning cohort (northern) N = 405 | Validating cohort (southern) N = 353 | |
|---|---|---|
Age (year) (median, IQR) | 68 (59–77) | 67 (57–75) |
Apache II score (median, IQR) | 21 (15–28) | 19 (14–25) |
Body mass index (kg/m2, median, IQR) | 24.7 (22.8–27.7) | 24.7 (22.2–27.7) |
eGFR (ml/min/1.73 m2) | 48.5 (26.4–78.9) | 58.8 (33.5–93.5) |
PaO2/FiO2 (Kpa, median, IQR) | 19.4 (11.6–29.2) | 21 (13.6–28.9) |
Surfactant protein D (ng/mL, median, IQR) | 133.5 (77.3–308.0) | 112 (63.5–240.7) |
Club cell secretory protein 16 (ng/mL, median, IQR) | 25.4 (10.6–37.4) | 20.2 (7.7–37.9) |
Severe sepsis/septic shock, n (%) | 158 (39.0) | 149 (42.2) |
Charlson’s comorbidity index, n (%) | ||
0 | 130 (32.1) | 136 (38.5) |
1 | 139 (34.3) | 108 (30.6) |
2 | 79 (19.5) | 65 (18.4) |
3 | 34 (8.4) | 30 (8.5) |
4 | 13 (3.2) | 8 (2.3) |
5 | 6 (1.5) | 2 (0.6) |
6 | 4 (1.0) | 3 (0.9) |
7 | 0 (0.0) | 1 (0.3) |
COPD, n (%) | 81 (20.0) | 75 (21.3) |
Primary admittance cause/acute diagnosis category (%) | ||
Pneumonia | 137 (33.8) | 117 (33.1) |
Abdominal sepsis | 65 (16.1) | 76 (21.5) |
Sepsis of other cause | 48 (11.9) | 42 (11.9) |
Heart failure | 47 (11.6) | 34 (9.6) |
Thrombosis or bleeding | 52 (12.8) | 20 (5.7) |
Other | 56 (13.8) | 64 (18.1) |
Gender, n (%) | ||
Female | 184 (45.4) | 163 (46.2) |
Male | 221 (54.6) | 190 (53.8) |