Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial

Annals of Intensive Care

Table 2 Predictors of successful weaning from mechanical ventilation within 28 days—multivariable competing risk Cox regression

	Learning cohort (northern) N = 405				Validating cohort (southern) N = 353
	P value	Hazard ratio	95% CI for HR		P value	Hazard ratio	95% CI for HR
	P value	Hazard ratio	Lower	Upper	P value	Hazard ratio	Lower	Upper
Surfactant protein D (≥85th percentile in “learning cohort,” ≥525.6 ng/mL vs. <525.6 ng/mL)	0.0053	0.60	0.42	0.86	0.046	0.64	0.42	0.99
Club cell secretory protein 16 (≥85th percentile in “learning cohort,” ≥42.8 ng/mL vs. <42.8 ng/mL)	0.50	0.89	0.66	1.22	0.81	0.96	0.67	1.37
PaO₂/FiO₂ (Q1 vs. Q2–Q4)	0.017	0.73	0.57	0.95	0.89	0.98	0.73	1.32
Apache II score (per score unit increase)	0.031	0.986	0.974	0.999	0.041	0.981	0.964	0.999
Age (per year increase)	0.84	1.00	0.992	1.010	0.17	0.993	0.984	1.003
Severe sepsis/Septic shock (vs. milder or no infection)	0.0014	0.66	0.51	0.85	0.0019	0.63	0.48	0.85
Charlson’s comorbidity index ≥2 vs. <2	0.046	1.29	1.00	1.67	0.58	1.08	0.81	1.46
Chronic obstructive pulmonary disease (yes vs. no)	0.36	0.87	0.64	1.18	0.71	0.94	0.67	1.31
Gender (male vs. female)	0.82	0.97	0.77	1.23	0.97	1.01	0.77	1.32
Estimated glomerular filtration rate (per ml)	0.61	1.00	0.999	1.002	0.048	1.001	0.998	1.004

Adjusted Cox regression risk estimates for known, suspected and explored predictors of successful weaning from ventilator within 28 days. Death from all causes was entered in the model as a competing risk
Q1, quartile 1; eGFR, ml/min/1.73 m²