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Table 2 Predictors of successful weaning from mechanical ventilation within 28 days—multivariable competing risk Cox regression

From: Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial

  Learning cohort (northern) N = 405 Validating cohort (southern) N = 353
P value Hazard ratio 95% CI for HR P value Hazard ratio 95% CI for HR
Lower Upper Lower Upper
Surfactant protein D (≥85th percentile in “learning cohort,” ≥525.6 ng/mL vs. <525.6 ng/mL) 0.0053 0.60 0.42 0.86 0.046 0.64 0.42 0.99
Club cell secretory protein 16 (≥85th percentile in “learning cohort,” ≥42.8 ng/mL vs. <42.8 ng/mL) 0.50 0.89 0.66 1.22 0.81 0.96 0.67 1.37
PaO2/FiO2 (Q1 vs. Q2–Q4) 0.017 0.73 0.57 0.95 0.89 0.98 0.73 1.32
Apache II score (per score unit increase) 0.031 0.986 0.974 0.999 0.041 0.981 0.964 0.999
Age (per year increase) 0.84 1.00 0.992 1.010 0.17 0.993 0.984 1.003
Severe sepsis/Septic shock (vs. milder or no infection) 0.0014 0.66 0.51 0.85 0.0019 0.63 0.48 0.85
Charlson’s comorbidity index ≥2 vs. <2 0.046 1.29 1.00 1.67 0.58 1.08 0.81 1.46
Chronic obstructive pulmonary disease (yes vs. no) 0.36 0.87 0.64 1.18 0.71 0.94 0.67 1.31
Gender (male vs. female) 0.82 0.97 0.77 1.23 0.97 1.01 0.77 1.32
Estimated glomerular filtration rate (per ml) 0.61 1.00 0.999 1.002 0.048 1.001 0.998 1.004
  1. Adjusted Cox regression risk estimates for known, suspected and explored predictors of successful weaning from ventilator within 28 days. Death from all causes was entered in the model as a competing risk
  2. Q1, quartile 1; eGFR, ml/min/1.73 m2