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Table 3 Acute respiratory distress syndromea according to Berlin criteria—multivariable logistic regression

From: Prediction of non-recovery from ventilator-demanding acute respiratory failure, ARDS and death using lung damage biomarkers: data from a 1200-patient critical care randomized trial

  Learning cohort (northern) N = 405 Validating cohort (southern)
N = 353
P value Odds ratio 95% CI for OR P value Odds ratio 95% CI for OR
Lower Upper Lower Upper
Surfactant protein D (≥85th percentile in “learning cohort,” ≥525.6 ng/mL vs. <525.6 ng/mL) 0.042a 3.4 1.0 11.4 0.003a 8.4 2.0 35.4
Club cell secretory protein 16 (≥85th percentile in “learning cohort,” ≥42.8 ng/mL vs. <42.8 ng/mL) 0.14 2.6 0.7 9.7 1.0 0.96 0.20 4.5
PaO2/FiO2 (Q1 vs. Q2-Q4) 0.076 2.9 0.9 9.1 0.001a 9.3 2.6 33.7
Apache II score (per score unit increase) 0.23 1.025 0.984 1.067 0.57 1.023 0.946 1.106
Age (per year increase) 0.56 1.015 0.965 1.067 0.26 0.974 0.93 1.02
Severe sepsis/septic shock (vs. milder or no infection) 0.19 2.1 0.68 6.8 0.06 3.6 0.96 13.6
Charlson’s comorbidity index ≥2 vs. <2 0.23 0.41 0.10 1.7 0.12 0.28 0.053 1.42
Chronic obstructive pulmonary disease (yes vs. no) 0.74 0.76 0.15 3.8 0.65 1.43 0.30 6.7
Gender (male vs. female) 0.32 0.56 0.18 1.74 0.67 1.30 0.40 4.2
Estimated glomerular filtration rate (per ml increase) 0.19 1.005 0.998 1.011 0.61 1.003 0.992 1.01
  1. Adjusted logistic regression risk estimates for known, suspected and explored predictors of ARDS. Abbreviations: Q1: quartile 1
  2. Biomarker levels were not known for radiologists and ICU physicians who diagnosed ARDS
  3. OR, odds ratio
  4. aAll severities (mild, moderate, severe) of ARDS were counted